RYR2: ryanodine receptor 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4jkq chain A
6y4o chain B
6y4p chain B
7kl5 chain B
7u9q chain A
7u9q chain B
7u9q chain C
7u9q chain D
7u9r chain A
7u9r chain B
7u9r chain C
7u9r chain D
7u9t chain A
7u9t chain B
7u9t chain C
7u9t chain D
7u9x chain A
7u9x chain B
7u9x chain C
7u9x chain D
7u9z chain A
7u9z chain B
7u9z chain C
7u9z chain D
7ua1 chain A
7ua1 chain B
7ua1 chain C
7ua1 chain D
7ua3 chain A
7ua3 chain B
7ua3 chain C
7ua3 chain D
7ua4 chain A
7ua4 chain B
7ua4 chain C
7ua4 chain D
7ua5 chain A
7ua5 chain B
7ua5 chain C
7ua5 chain D
7ua9 chain A
7ua9 chain B
7ua9 chain C
7ua9 chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S1495 VCAGESMS PGQGRNN 1 89 - - - - - - 89 - - - - - - - - - - - - - T1856 SVFKEAAT PEEESDT 1 80 - - - - - - 80 - - - - - - - - - - - - - S1861 AATPEEES DTLEKEL 1 18 - - - - - - 18 - - - - - - - - - - - - - S2363 DPSRDGPS PNSGSSK 1 99 - - - - - - 99 - - - - - - - - - - - - - S2366 RDGPSPNS GSSKTLD 1 9 - - - - - - 9 - - - - - - - - - - - - - S2368 GPSPNSGS SKTLDTE 1 9 - - - - - - 9 - - - - - - - - - - - - - S2694 SMMEKQSS MDSEGNF 1 98 - - - - - - 98 - - - - - - - - - - - - - S2697 EKQSSMDS EGNFNPQ 1 9 - - - - - - 9 - - - - - - - - - - - - - S2808 YNRTRRIS QTSQVSV 2 136 - - - - 29 34 73 - - - - - - - - - - - - - T2810 RTRRISQT SQVSVDA 1 45 - - - - 19 26 - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S1495 VCAGESMS PGQGRNN - - - - - - - - - - - T1856 SVFKEAAT PEEESDT - - - - - - - - - - - S1861 AATPEEES DTLEKEL - - - - - - - - - - - S2363 DPSRDGPS PNSGSSK - - - - - - - - - - - S2366 RDGPSPNS GSSKTLD - - - - - - - - - - - S2368 GPSPNSGS SKTLDTE - - - - - - - - - - - S2694 SMMEKQSS MDSEGNF - - - - - - - - - - - S2697 EKQSSMDS EGNFNPQ - - - - - - - - - - - S2808 YNRTRRIS QTSQVSV -0.032 - - -0.032 - - - - - - - T2810 RTRRISQT SQVSVDA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S1495
T1856
S1861
S2363
S2366
S2368
S2694
S2697
S2808
T2810
S2811
S2814
Y2956
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation CCRCC S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation COAD S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation GBM S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation HNSCC S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation LSCC S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation LUAD S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation OV S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation PDAC S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation UCEC S1495 T1856 S1861 S2363 S2366 S2368 S2694 S2697 S2808 T2810 S2811 S2814 Y2956 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S1495
T1856
S1861
S2363
S2366
S2368
S2694
S2697
S2808
T2810
S2811
S2814
Y2956
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S1495
T1856
S1861
S2363
S2366
S2368
S2694
S2697
S2808
T2810
S2811
S2814
Y2956
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.