EGLN1: egl-9 family hypoxia inducible factor 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2g19 chain A
2g1m chain A
2hbt chain A
2hbu chain A
2y33 chain A
2y34 chain A
3hqr chain A
3hqu chain A
3ouh chain A
3oui chain A
3ouj chain A
4bqw chain A
4bqx chain A
4bqy chain A
4jzr chain A
4kbz chain A
4uwd chain A
5a3u chain A
5a3u chain B
5a3u chain C
5l9b chain A
5l9b chain B
5l9r chain A
5l9v chain A
5l9v chain B
5la9 chain A
5la9 chain B
5las chain A
5las chain B
5lat chain A
5lb6 chain A
5lbb chain A
5lbc chain A
5lbe chain A
5lbf chain A
5ox5 chain A
5ox6 chain A
5v18 chain A
6nmq chain A
6qgv chain A
6st3 chain A
6st3 chain B
6yvt chain A
6yvt chain B
6yvt chain C
6yvt chain D
6yvt chain E
6yvt chain F
6yvw chain A
6yvx chain A
6yvz chain A
6yw0 chain A
6yw1 chain A
6yw2 chain A
6yw3 chain A
6yw4 chain A
6zbn chain A
6zbn chain B
6zbn chain C
6zbn chain D
6zbn chain E
6zbn chain F
6zbo chain A
6zbo chain B
6zbo chain C
6zbo chain D
6zbo chain E
6zbo chain F
7ump chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S39 RCSRCRSS FYCCKEH 8 479 22 - 59 55 - - 9 - 74 43 68 60 4 4 - - 26 13 37 5 S61 HKLVCQGS EGALGHG 2 61 - - 3 3 - - 55 - - - - - - - - - - - - - S125 ADPAAAAS PCRAAAG 10 1348 122 - 81 60 70 73 99 - 101 59 103 94 84 77 75 18 88 37 89 18 T168 NLYPPSNT PGDALSP 2 25 - - - - - - - - - - - - 10 8 - - 5 2 - - S174 NTPGDALS PGGGLRP 4 160 - - - - - - 45 - 12 7 5 4 - - - - - - 78 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S39 RCSRCRSS FYCCKEH 1.8e-18 - 0.27 - - 2.5e-6 2.6e-14 - - 4.0e-5 - S61 HKLVCQGS EGALGHG - - - - - - - - - - - S125 ADPAAAAS PCRAAAG 9.8e-4 - 5.1e-16 -1.5e-9 - -6.5e-3 0.57 8.4e-3 9.3e-3 5.7e-4 0.46 T168 NLYPPSNT PGDALSP - - - - - - - - - - - S174 NTPGDALS PGGGLRP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S39
S61
S125
T168
S174
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S39 S61 S125 T168 S174 protein RNA SCNV methylation CCRCC S39 S61 S125 T168 S174 protein RNA SCNV methylation COAD S39 S61 S125 T168 S174 protein RNA SCNV methylation GBM S39 S61 S125 T168 S174 protein RNA SCNV methylation HNSCC S39 S61 S125 T168 S174 protein RNA SCNV methylation LSCC S39 S61 S125 T168 S174 protein RNA SCNV methylation LUAD S39 S61 S125 T168 S174 protein RNA SCNV methylation OV S39 S61 S125 T168 S174 protein RNA SCNV methylation PDAC S39 S61 S125 T168 S174 protein RNA SCNV methylation UCEC S39 S61 S125 T168 S174 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S39
S61
S125
T168
S174
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S39
S61
S125
T168
S174
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.