PRKN: parkin RBR E3 ubiquitin protein ligase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1iyf chain A
2jmo chain A
4bm9 chain A
4i1f chain A
4i1h chain A
5c1z chain A
5c1z chain B
5c23 chain A
5c23 chain B
5c9v chain A
5n2w chain A
5n38 chain A
5tr5 chain A
6glc chain A
6hue chain A
6hue chain B
6n13 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S131 HTDSRKDS PPAGSPA 8 812 74 - 78 64 - - 99 - 57 35 78 72 84 77 - - 45 17 23 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S131 HTDSRKDS PPAGSPA -9.7e-32 - -7.8e-19 - - -4.2e-7 -1.5e-12 -2.5e-10 - 0.27 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S131
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S131 protein RNA SCNV methylation CCRCC S131 protein RNA SCNV methylation COAD S131 protein RNA SCNV methylation GBM S131 protein RNA SCNV methylation HNSCC S131 protein RNA SCNV methylation LSCC S131 protein RNA SCNV methylation LUAD S131 protein RNA SCNV methylation OV S131 protein RNA SCNV methylation PDAC S131 protein RNA SCNV methylation UCEC S131 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S131
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S131
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.