EPRS1: glutamyl-prolyl-tRNA synthetase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1fyj chain A
4hvc chain A
4hvc chain B
4k86 chain A
4k87 chain A
4k88 chain A
5a1n chain A
5a34 chain A
5a34 chain C
5a34 chain E
5a34 chain G
5a5h chain A
5a5h chain C
5a5h chain E
5a5h chain G
5bmu chain B
5bmu chain D
5bmu chain F
5bmu chain H
5v58 chain A
5vad chain A
5vad chain B
5y6l chain C
6iy6 chain E
6iy6 chain F
6iy6 chain K
6iy6 chain L
7bbu chain A
7f99 chain A
7f99 chain B
7f9c chain A
7f9c chain B
7osy chain A
7osy chain B
7osz chain A
7osz chain B
7ot0 chain A
7ot0 chain B
7ot1 chain A
7ot1 chain B
7ot2 chain A
7ot2 chain B
7ot3 chain A
7ot3 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T431 SRLNLNNT VLSKRKL 1 16 - - - - - - - - - - - - 8 8 - - - - - - S434 NLNNTVLS KRKLTWF 9 872 71 - 54 36 - - 90 - 47 24 98 89 40 36 28 6 99 41 95 18 T467 GVLRRGMT VEGLKQF 8 367 35 - 49 38 - - 90 - 35 21 5 5 9 8 - - 31 15 12 14 S480 QFIAAQGS SRSVVNM 2 17 - - - - 2 7 - - - - - - - - - - - - 6 2 S481 FIAAQGSS RSVVNME 1 8 - - - - - - - - - - - - - - - - - - 6 2 S483 AAQGSSRS VVNMEWD 1 18 - - - - - - - - 11 7 - - - - - - - - - - Y684 FFICDQPY EPVSPYS 5 77 16 - 4 4 - - - - 11 7 5 5 13 12 - - - - - - S688 DQPYEPVS PYSCKEA 6 104 8 - - - - - 27 - 18 10 15 14 - - - - 3 2 5 2 T712 GHTKEMPT SGSKEKT 6 112 28 - - - - - 9 - 12 6 4 4 18 16 - - 10 5 - - S715 KEMPTSGS KEKTKVE 5 315 - - - - - - 37 - 35 20 30 27 - - - - 78 31 53 4
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T431 SRLNLNNT VLSKRKL - - - - - - - - - - - S434 NLNNTVLS KRKLTWF -0.46 - -5.8e-8 - - -0.94 6.7e-12 2.7e-3 - -2e-12 6.6e-6 T467 GVLRRGMT VEGLKQF -0.023 - 9.0e-4 - - -4.9e-5 - - - -1.4e-3 - S480 QFIAAQGS SRSVVNM - - - - - - - - - - - S481 FIAAQGSS RSVVNME - - - - - - - - - - - S483 AAQGSSRS VVNMEWD - - - - - - - - - - - Y684 FFICDQPY EPVSPYS - - - - - - - - - - - S688 DQPYEPVS PYSCKEA - - - - - - - - - - - T712 GHTKEMPT SGSKEKT - - - - - - - - - - - S715 KEMPTSGS KEKTKVE -2.2e-6 - - - - -5.6e-5 0.01 - - -1.6e-11 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T431
S434
T467
S480
S481
S483
Y684
S688
T712
S715
T737
S739
T745
T746
S747
S813
S814
S816
S817
S819
S825
S845
S880
S882
S883
S885
S886
T888
S891
T898
S910
S944
Y950
S954
S998
S999
S1000
S1085
S1336
S1350
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation CCRCC T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation COAD T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation GBM T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation HNSCC T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation LSCC T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation LUAD T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation OV T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation PDAC T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation UCEC T431 S434 T467 S480 S481 S483 Y684 S688 T712 S715 T737 S739 T745 T746 S747 S813 S814 S816 S817 S819 S825 S845 S880 S882 S883 S885 S886 T888 S891 T898 S910 S944 Y950 S954 S998 S999 S1000 S1085 S1336 S1350 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T431
S434
T467
S480
S481
S483
Y684
S688
T712
S715
T737
S739
T745
T746
S747
S813
S814
S816
S817
S819
S825
S845
S880
S882
S883
S885
S886
T888
S891
T898
S910
S944
Y950
S954
S998
S999
S1000
S1085
S1336
S1350
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T431
S434
T467
S480
S481
S483
Y684
S688
T712
S715
T737
S739
T745
T746
S747
S813
S814
S816
S817
S819
S825
S845
S880
S882
S883
S885
S886
T888
S891
T898
S910
S944
Y950
S954
S998
S999
S1000
S1085
S1336
S1350
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.