PTPN14: protein tyrosine phosphatase non-receptor type 14
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2bzl chain A
6iwd chain A
6jjw chain U
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S312 NKICTEQS NSPPPIR 2 32 - - 16 8 - - - - - - - - - - - - 5 3 - - S314 ICTEQSNS PPPIRRQ 10 1535 122 - 103 80 86 93 99 - 108 62 108 99 110 101 83 19 105 44 95 18 T323 PPIRRQPT WSRSSLP 9 372 15 - 22 20 28 17 27 - 19 15 29 28 22 22 57 12 - - 28 11 S432 YIPSHRHS AIIVPSY 9 573 78 - 54 44 - - 53 - 83 50 63 57 13 12 37 8 5 1 13 2 S438 HSAIIVPS YRPTPDY 1 9 - - - - - - - - - - - - - - 8 1 - - - - S461 RGILHTDS QSQSLRN 9 270 15 - 17 16 4 5 - - 17 11 24 21 5 4 49 11 35 16 16 4 S463 ILHTDSQS QSLRNLN 6 130 8 - 20 12 - - - - 6 3 25 23 8 8 - - 12 5 - - S465 HTDSQSQS LRNLNII 10 696 17 - 47 41 10 8 18 - 86 47 64 58 59 53 83 19 43 20 19 4 Y485 NQPEDLVY SQPEMRE 7 236 14 - 52 33 - - - - 6 3 25 22 29 24 13 3 9 3 - - S486 QPEDLVYS QPEMRER 10 718 50 - 26 24 19 26 99 - 28 17 29 26 72 63 61 15 41 15 89 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S312 NKICTEQS NSPPPIR - - - - - - - - - - - S314 ICTEQSNS PPPIRRQ 4.7e-6 - 9.6e-9 -6.4e-3 - 5.6e-16 0.81 -1e-8 -0.48 1.3e-12 0.35 T323 PPIRRQPT WSRSSLP -0.39 - -0.27 0.037 - - -0.15 -0.31 2.7e-3 - -3.0e-4 S432 YIPSHRHS AIIVPSY 0.045 - 2.1e-5 - - 9.2e-3 -7.3e-4 - - - - S438 HSAIIVPS YRPTPDY - - - - - - - - - - - S461 RGILHTDS QSQSLRN 2.4e-4 - - - - - 0.14 - 1.1e-3 0.1 - S463 ILHTDSQS QSLRNLN 0.22 - 0.69 - - - 0.18 - - - - S465 HTDSQSQS LRNLNII 0.07 - 1.2e-4 - - 1.7e-7 -4.5e-4 -2.8e-10 3.7e-4 0.11 - Y485 NQPEDLVY SQPEMRE -0.19 - 0.012 - - - -0.94 -2.6e-6 - - - S486 QPEDLVYS QPEMRER -0.17 - 7.2e-3 - - -0.99 -0.22 -4.2e-10 0.031 1.6e-3 -3.8e-5
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S312
S314
T323
S432
S438
S461
S463
S465
Y485
S486
S512
S538
T539
S578
T579
S591
S593
S594
S605
S614
S620
S625
S642
S660
T670
S707
S708
S710
S758
S760
S803
S807
S809
S831
S835
S879
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation CCRCC S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation COAD S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation GBM S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation HNSCC S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation LSCC S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation LUAD S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation OV S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation PDAC S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation UCEC S312 S314 T323 S432 S438 S461 S463 S465 Y485 S486 S512 S538 T539 S578 T579 S591 S593 S594 S605 S614 S620 S625 S642 S660 T670 S707 S708 S710 S758 S760 S803 S807 S809 S831 S835 S879 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S312
S314
T323
S432
S438
S461
S463
S465
Y485
S486
S512
S538
T539
S578
T579
S591
S593
S594
S605
S614
S620
S625
S642
S660
T670
S707
S708
S710
S758
S760
S803
S807
S809
S831
S835
S879
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S312
S314
T323
S432
S438
S461
S463
S465
Y485
S486
S512
S538
T539
S578
T579
S591
S593
S594
S605
S614
S620
S625
S642
S660
T670
S707
S708
S710
S758
S760
S803
S807
S809
S831
S835
S879
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.