NEK2: NIMA related kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2jav chain A
2w5a chain A
2w5b chain A
2w5h chain A
2wqo chain A
2xk3 chain A
2xk4 chain A
2xk6 chain A
2xk7 chain A
2xk8 chain A
2xkc chain A
2xkd chain A
2xke chain A
2xkf chain A
2xnm chain A
2xnn chain A
2xno chain A
2xnp chain A
4a4x chain A
4afe chain A
5m51 chain A
5m53 chain A
5m55 chain A
5m57 chain A
6sgd chain A
6sgh chain A
6sgi chain A
6sgk chain A
6sk9 chain A
6tm5 chain Q
6tm5 chain S
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S184 VGTPYYMS PEQMNRM 1 15 - - - - - - - - - - - - - - - - - - 10 5 S296 QLGEPEKS QDSSPVL 1 18 - - - - - - - - - - - - - - - - - - 7 11 S300 PEKSQDSS PVLSELK 2 49 30 - - - - - - - - - - - - - - - - - 17 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S184 VGTPYYMS PEQMNRM - - - - - - - - - - - S296 QLGEPEKS QDSSPVL - - - - - - - - - - - S300 PEKSQDSS PVLSELK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S184
S296
S300
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S184 S296 S300 protein RNA SCNV methylation CCRCC S184 S296 S300 protein RNA SCNV methylation COAD S184 S296 S300 protein RNA SCNV methylation GBM S184 S296 S300 protein RNA SCNV methylation HNSCC S184 S296 S300 protein RNA SCNV methylation LSCC S184 S296 S300 protein RNA SCNV methylation LUAD S184 S296 S300 protein RNA SCNV methylation OV S184 S296 S300 protein RNA SCNV methylation PDAC S184 S296 S300 protein RNA SCNV methylation UCEC S184 S296 S300 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S184
S296
S300
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S184
S296
S300
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.