SYNE1: spectrin repeat containing nuclear envelope protein 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4dxr chain B
6r15 chain B
6xf2 chain A
6xf2 chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S379 LHRDGKLS LDQALVK 1 8 - - - - - - - - - - - - 4 4 - - - - - - S1244 YKEIVKNS LEELISG 2 70 - - - - - - 62 - - - 4 4 - - - - - - - - S1371 ERFLSFSS LESLSSE 6 277 - - 7 5 - - 68 - 53 32 14 13 40 36 - - - - - 9 S1374 LSFSSLES LSSELEQ 1 8 - - 4 4 - - - - - - - - - - - - - - - - S1377 SSLESLSS ELEQTKE 1 9 - - - - - - 9 - - - - - - - - - - - - - S1680 RGEAKASS PEMDISA 1 36 - - - - - - 36 - - - - - - - - - - - - - T2270 ELTKNLET PPDLQFI 1 61 - - - - - - 61 - - - - - - - - - - - - - S3030 LNELCRFS RDLSTYS 2 18 - - 5 4 - - - - - - - - 5 4 - - - - - - S3622 KTAEEKVS PRTRRQS 1 10 - - - - - - - - - - 5 5 - - - - - - - - S4062 VQPDLEPS PQPPLSR 1 60 - - - - - - 60 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S379 LHRDGKLS LDQALVK - - - - - - - - - - - S1244 YKEIVKNS LEELISG - - - - - - - - - - - S1371 ERFLSFSS LESLSSE -5.5e-20 - - - - -9.6e-9 - -5.6e-13 - - - S1374 LSFSSLES LSSELEQ - - - - - - - - - - - S1377 SSLESLSS ELEQTKE - - - - - - - - - - - S1680 RGEAKASS PEMDISA - - - - - - - - - - - T2270 ELTKNLET PPDLQFI - - - - - - - - - - - S3030 LNELCRFS RDLSTYS - - - - - - - - - - - S3622 KTAEEKVS PRTRRQS - - - - - - - - - - - S4062 VQPDLEPS PQPPLSR - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S379
S1244
S1371
S1374
S1377
S1680
T2270
S3030
S3622
S4062
S4161
S4374
S5657
S5858
S5864
S5875
S5881
S5883
T5888
S5891
S5917
T5918
S5919
S5921
S5943
S6175
S6200
S6209
S6230
S6334
S6353
S6376
S6430
S8074
S8223
S8247
S8250
S8254
S8255
S8258
T8274
S8277
S8280
S8305
T8360
T8362
S8369
S8383
S8386
S8664
S8665
S8674
T8680
S8683
S8685
S8704
S8706
S8713
S8724
S8726
S8727
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation CCRCC S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation COAD S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation GBM S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation HNSCC S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation LSCC S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation LUAD S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation OV S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation PDAC S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation UCEC S379 S1244 S1371 S1374 S1377 S1680 T2270 S3030 S3622 S4062 S4161 S4374 S5657 S5858 S5864 S5875 S5881 S5883 T5888 S5891 S5917 T5918 S5919 S5921 S5943 S6175 S6200 S6209 S6230 S6334 S6353 S6376 S6430 S8074 S8223 S8247 S8250 S8254 S8255 S8258 T8274 S8277 S8280 S8305 T8360 T8362 S8369 S8383 S8386 S8664 S8665 S8674 T8680 S8683 S8685 S8704 S8706 S8713 S8724 S8726 S8727 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S379
S1244
S1371
S1374
S1377
S1680
T2270
S3030
S3622
S4062
S4161
S4374
S5657
S5858
S5864
S5875
S5881
S5883
T5888
S5891
S5917
T5918
S5919
S5921
S5943
S6175
S6200
S6209
S6230
S6334
S6353
S6376
S6430
S8074
S8223
S8247
S8250
S8254
S8255
S8258
T8274
S8277
S8280
S8305
T8360
T8362
S8369
S8383
S8386
S8664
S8665
S8674
T8680
S8683
S8685
S8704
S8706
S8713
S8724
S8726
S8727
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S379
S1244
S1371
S1374
S1377
S1680
T2270
S3030
S3622
S4062
S4161
S4374
S5657
S5858
S5864
S5875
S5881
S5883
T5888
S5891
S5917
T5918
S5919
S5921
S5943
S6175
S6200
S6209
S6230
S6334
S6353
S6376
S6430
S8074
S8223
S8247
S8250
S8254
S8255
S8258
T8274
S8277
S8280
S8305
T8360
T8362
S8369
S8383
S8386
S8664
S8665
S8674
T8680
S8683
S8685
S8704
S8706
S8713
S8724
S8726
S8727
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.