Protein: ENSP00000357430
Gene: SHC1

LinkedOmicsKB © 2022-2023 Zhang Lab

SHC1:
SHC adaptor protein 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S80PAGGRPGSKGEPGRA294--------553054--------
S115LQDMNKLSGGGGRRT6615------27---988984773679738566
S139EEWTRHGSFVNKPTR10108622-4039909846-884968631059736795389015
T324RNPPKLVTPHDRMAG526721---------302730277518--309
Y349EEPPDHQYYNDFPGK876081-46254139--844374689285--745318
Y350EPPDHQYYNDFPGKE745881-46254139--844398----745318
T386PTAPNAQTPSHLGAT17--------------61----
S388APNAQTPSHLGATLP199-------------------
Y427ELFDDPSYVNVQNLD101492108-99769610099-1045810395100938319105449218
S453PNPAINGSAPRDLFD1077588-553611718-331878721059722447204816
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S80PAGGRPGSKGEPGRA2.2e-5----2.2e-5-----
S115LQDMNKLSGGGGRRT7.6e-27-----3.6e-91.4e-7-1.3e-13-
S139EEWTRHGSFVNKPTR0.023-9.9e-13-4.1e-5-0.15-0.21-0.99-7e-11-2.4e-4
T324RNPPKLVTPHDRMAG-0.12------3.8e-4-0.770.25--
Y349EEPPDHQYYNDFPGK-1.1e-13-3.5e-5-1.1e-5--1.5e-13-6.1e-7-2.7e-6---0.39
Y350EPPDHQYYNDFPGKE-2.1e-5-3.5e-5-1.1e-5--1.5e-13-----0.39
T386PTAPNAQTPSHLGAT-----------
S388APNAQTPSHLGATLP-----------
Y427ELFDDPSYVNVQNLD-1.7e-17-1.1e-12-3.3e-10--7.1e-16-2.8e-10-1.6e-6-0.026-0.78-1.3e-3
S453PNPAINGSAPRDLFD-0.18--6.6e-3--0.0280.210.46--3.7e-5-0.52
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationCCRCCS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationCOADS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationGBMS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationHNSCCS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationLSCCS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationLUADS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationOVS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationPDACS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylationUCECS80S115S139T324Y349Y350T386S388Y427S453T516proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.