REV3L: REV3 like, DNA directed polymerase zeta catalytic subunit
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3abd chain X
3abd chain Y
3abe chain Z
3vu7 chain Z
4ext chain B
4gk0 chain C
4gk0 chain D
4gk5 chain C
4gk5 chain D
5o8k chain B
6bc8 chain B
6bcd chain B
6bi7 chain B
6bi7 chain D
6bi7 chain F
6bi7 chain H
6ekm chain B
6ws0 chain ZZZ
6ws5 chain ZZZ
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S402 LTQRLSES PVFMDSS 1 9 - - - - 4 5 - - - - - - - - - - - - - - S435 GERNRMPS PCRSFGN 2 34 - - - - - - - - 9 6 10 9 - - - - - - - - S449 NNKYPQNS DDEENEP 7 462 - - 12 10 - - 90 - 68 39 39 36 22 20 - - 21 10 77 18 S600 EDLIEDLS QTNKNTE 1 4 - - - - - - - - - - - - - - - - - - 4 - S1030 FWPKVPDS PATKYPI 6 350 30 - 8 8 - - 36 - 53 34 69 63 - - - - - - 38 11 T1041 KYPIYPLT PKKSHRR 3 63 9 - - - - - - - - - 5 4 - - - - - - 34 11 S1089 HAILSPPS PSYNAET 1 9 - - - - - - - - - - - - - - - - - - - 9 S1114 MSKLGFLS ERSTSPI 4 299 38 - - - - - - - - - 88 82 37 31 - - - - 12 11 S1119 FLSERSTS PINSSPP 4 66 15 - - - - - 9 - - - - - - - 8 1 - - 22 11 S1123 RSTSPINS SPPRCWS 1 8 - - - - - - - - - - - - - - - - - - 8 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S402 LTQRLSES PVFMDSS - - - - - - - - - - - S435 GERNRMPS PCRSFGN - - - - - - - - - - - S449 NNKYPQNS DDEENEP -0.87 - - - - 1.6e-4 0.14 0.18 - -8.6e-5 -2.6e-3 S600 EDLIEDLS QTNKNTE - - - - - - - - - - - S1030 FWPKVPDS PATKYPI 1.1e-6 - - - - 0.18 1.4e-17 - - - -0.16 T1041 KYPIYPLT PKKSHRR -0.8 - - - - - - - - - -0.8 S1089 HAILSPPS PSYNAET - - - - - - - - - - - S1114 MSKLGFLS ERSTSPI 0.35 - - - - - 8.6e-4 -0.046 - - - S1119 FLSERSTS PINSSPP -2.1e-3 - - - - - - - - - -2.1e-3 S1123 RSTSPINS SPPRCWS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S402
S435
S449
S600
S1030
T1041
S1089
S1114
S1119
S1123
S1124
S1130
T1132
S1406
S1443
S1497
T1516
S1724
S1755
S1757
T1871
T1960
S1967
S2056
S2101
S2147
S2171
S2220
T2259
S2862
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation CCRCC S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation COAD S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation GBM S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation HNSCC S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation LSCC S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation LUAD S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation OV S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation PDAC S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation UCEC S402 S435 S449 S600 S1030 T1041 S1114 S1119 S1123 S1124 S1130 T1132 S1406 S1443 S1497 T1516 S1724 S1755 S1757 T1871 T1960 S1967 S2101 S2147 S2171 S2220 T2259 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S402
S435
S449
S600
S1030
T1041
S1089
S1114
S1119
S1123
S1124
S1130
T1132
S1406
S1443
S1497
T1516
S1724
S1755
S1757
T1871
T1960
S1967
S2056
S2101
S2147
S2171
S2220
T2259
S2862
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S402
S435
S449
S600
S1030
T1041
S1089
S1114
S1119
S1123
S1124
S1130
T1132
S1406
S1443
S1497
T1516
S1724
S1755
S1757
T1871
T1960
S1967
S2056
S2101
S2147
S2171
S2220
T2259
S2862
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.