Protein: ENSP00000358092
Gene: PRDM1

LinkedOmicsKB © 2022-2023 Zhang Lab

PRDM1:
PR/SET domain 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S272DLYRSNISPLTSEKD995180-513945--10258104949285223100405616
S288DDFRRRGSPEMPFYP984847-16162617--108621089896867165245516
S336IPSSTTPSPSARSSP256--------17101514--------
S341TPSPSARSSPDQSLK5100--44----352155108----53
S342PSPSARSSPDQSLKS1034942-44271827-171030292121711055818
S351DQSLKSSSPHSSPGN2138-------------41----
S511SMKDKACSPTSGSPT223--------------81--113
T513KDKACSPTSGSPTAG16------------------6-
S514DKACSPTSGSPTAGT15------------------5-
S516ACSPTSGSPTAGTAA712017-----9-54545471--4316
Showing 1 to 10 of 12 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S272DLYRSNISPLTSEKD9.5e-27-1.2e-14---0.0197.1e-291.9e-16-1.2e-5-3.8e-3
S288DDFRRRGSPEMPFYP1.2e-5--0.63-0.416.7e-220.17--0.0350.58
S336IPSSTTPSPSARSSP-----------
S341TPSPSARSSPDQSLK4.8e-3----4.8e-3-----
S342PSPSARSSPDQSLKS1.8e-13--1.3e-5--6e-128.5e-8---0.062
S351DQSLKSSSPHSSPGN-----------
S511SMKDKACSPTSGSPT-----------
T513KDKACSPTSGSPTAG-----------
S514DKACSPTSGSPTAGT-----------
S516ACSPTSGSPTAGTAA-4.3e-4----------4.3e-4
Showing 1 to 10 of 12 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: B cell plasmaS2721.9e-249.2e-7-0.42--1.3e-82.2e-162.2e-160.320.021-0.53
xcell: microenvironment scoreS2725.6e-235.3e-57.8e-3--1.8e-42.2e-162.3e-40.270.0310.021
xcell: B cellS2725.4e-221.9e-50.86--3.8e-74.9e-183e-70.120.020.95
xcell: immune scoreS2721.1e-202.6e-70.68--4.8e-52.2e-161.1e-40.287.4e-30.36
HALLMARK_ALLOGRAFT_REJECTIONS2721.5e-202.5e-80.065--1.6e-32.2e-166.1e-30.230.010.33
ESTIMATE: ImmuneScoreS2722.2e-201.3e-70.1--8.5e-42.2e-163.2e-30.330.0160.17
ESTIMATE: ESTIMATEScoreS2721.6e-192.3e-40.037--0.0182.2e-162.4e-30.292.1e-30.041
HALLMARK_IL2_STAT5_SIGNALINGS2723.7e-174.6e-60.042--8.3e-35.2e-96.2e-30.150.0290.019
HALLMARK_COMPLEMENTS2722.1e-165.4e-70.15--4.7e-32.4e-100.280.133.6e-30.03
ESTIMATE: StromalScoreT5212.2e-16-2.2e-16--------
Showing 1 to 10 of 3096 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationCCRCCS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationCOADS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationGBMS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationHNSCCS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationLSCCS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationLUADS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationOVS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationPDACS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylationUCECS272S288S336S341S342S351S511T513S514S516T518T521proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.