MAP3K7: mitogen-activated protein kinase kinase kinase 7
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2eva chain A
2yiy chain A
4gs6 chain A
4l3p chain A
4l52 chain A
4l53 chain A
4o91 chain A
5e7r chain A
5gjd chain A
5gjf chain A
5gjg chain A
5j7s chain A
5j8i chain A
5j9l chain A
5jga chain A
5jgb chain A
5jgd chain A
5jh6 chain A
5jk3 chain A
5v5n chain A
7nth chain A
7nti chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S192 HMTNNKGS AAWMAPE 7 162 - - 4 4 - - 9 - 32 17 14 12 12 12 - - 11 4 17 14 Y304 PLQYPCQY SDEGQSN 2 16 - - - - - - - - - - 5 5 - - - - - - 6 - S305 LQYPCQYS DEGQSNS 2 18 - - - - - - - - - - 5 5 - - - - - - 5 3 T314 EGQSNSAT STGSFMD 5 69 - - 4 2 - - 9 - 22 12 - - - - - - 9 2 7 2 T316 QSNSATST GSFMDIA 1 18 - - - - - - - - 12 6 - - - - - - - - - - S318 NSATSTGS FMDIAST 1 10 - - - - - - - - 6 4 - - - - - - - - - - S328 DIASTNTS NKSDTNM 4 64 - - - - - - 15 - - - 10 9 5 4 - - - - 17 4 S331 STNTSNKS DTNMEQV 2 188 - - - - - - 90 - - - - - - - - - - - 89 9 T333 NTSNKSDT NMEQVPA 1 6 - - 3 3 - - - - - - - - - - - - - - - - S367 QSESGRLS LGASRGS 7 780 - - 30 17 - - 73 - 85 51 103 94 85 77 - - 48 18 81 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S192 HMTNNKGS AAWMAPE 0.038 - - - - 0.038 - - - - - Y304 PLQYPCQY SDEGQSN - - - - - - - - - - - S305 LQYPCQYS DEGQSNS - - - - - - - - - - - T314 EGQSNSAT STGSFMD 0.25 - - - - 0.25 - - - - - T316 QSNSATST GSFMDIA - - - - - - - - - - - S318 NSATSTGS FMDIAST - - - - - - - - - - - S328 DIASTNTS NKSDTNM - - - - - - - - - - - S331 STNTSNKS DTNMEQV - - - - - - - - - - - T333 NTSNKSDT NMEQVPA - - - - - - - - - - - S367 QSESGRLS LGASRGS 5.4e-9 - 1.1e-5 - - 9.3e-11 -0.3 6.8e-3 - 2.9e-4 -0.059
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S192
Y304
S305
T314
T316
S318
S328
S331
T333
S367
S374
S375
S378
S389
T415
S417
S430
S439
S454
S455
T471
S472
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation CCRCC S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation COAD S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation GBM S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation HNSCC S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation LSCC S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation LUAD S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation OV S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation PDAC S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation UCEC S192 Y304 S305 T314 T316 S318 S328 S331 T333 S367 S374 S375 S378 S389 T415 S417 S430 S439 S454 S455 T471 S472 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S192
Y304
S305
T314
T316
S318
S328
S331
T333
S367
S374
S375
S378
S389
T415
S417
S430
S439
S454
S455
T471
S472
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S192
Y304
S305
T314
T316
S318
S328
S331
T333
S367
S374
S375
S378
S389
T415
S417
S430
S439
S454
S455
T471
S472
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.