ARFGAP1: ADP ribosylation factor GTPase activating protein 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3dwd chain A
3dwd chain B
3o47 chain A
3o47 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S125 LAEGREWS LESSPAQ 6 180 33 - 4 4 - - 63 - 12 7 25 23 - - - - - - - 9 S128 GREWSLES SPAQNWT 1 9 - - - - - - - - - - - - - - - - - - 7 2 S129 REWSLESS PAQNWTP 4 50 - - 4 3 - - - - - - 9 9 9 8 - - - - 8 - T135 SSPAQNWT PPQPRTL 8 852 71 - 41 40 - - 46 - 70 46 87 81 66 61 - - 96 41 88 18 S150 PSMVHRVS GQPQSVT 8 948 78 - 57 46 - - 99 - 103 59 79 72 67 61 - - 96 39 79 13 S155 RVSGQPQS VTASSDK 8 438 49 - 43 24 - - 18 - 44 27 64 58 22 21 - - 20 11 33 4 S159 QPQSVTAS SDKAFED 5 99 - - - - - - 62 - 5 3 - - 9 8 - - 2 1 - 9 S160 PQSVTASS DKAFEDW 8 367 17 - 4 4 - - 62 - 54 30 23 22 4 4 - - 50 20 66 7 S174 WLNDDLGS YQGAQGN 8 470 56 - 48 30 - - 46 - 12 5 39 35 92 85 - - 4 2 12 4 T189 RYVGFGNT PPPQKKE 8 1254 122 - 103 80 - - 99 - 108 62 108 99 110 101 - - 105 44 95 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S125 LAEGREWS LESSPAQ 0.31 - - - - - 0.31 - - - - S128 GREWSLES SPAQNWT - - - - - - - - - - - S129 REWSLESS PAQNWTP - - - - - - - - - - - T135 SSPAQNWT PPQPRTL 4.1e-13 - 1.5e-12 - - 0.35 0.15 1.5e-8 - 0.56 0.039 S150 PSMVHRVS GQPQSVT 0.041 - 1.6e-5 - - 0.09 0.89 1.5e-3 - -0.32 -0.001 S155 RVSGQPQS VTASSDK 1.8e-6 - 9.1e-3 - - 2.6e-5 0.056 2.3e-5 - -0.023 - S159 QPQSVTAS SDKAFED - - - - - - - - - - - S160 PQSVTASS DKAFEDW 0.049 - - - - 7.5e-3 9.2e-7 - - -2.9e-5 - S174 WLNDDLGS YQGAQGN 3.3e-5 - 1.8e-5 - - - 0.019 0.58 - - - T189 RYVGFGNT PPPQKKE 0.033 - 0.92 - - 2.0e-4 -1.1e-11 2.8e-6 - 9.6e-6 -0.36
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S125
S128
S129
T135
S150
S155
S159
S160
S174
T189
S206
S237
S246
S273
S284
S304
S306
S314
T340
S343
S345
S346
S348
T350
T354
S355
S360
S361
S363
S369
S376
S378
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation CCRCC S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation COAD S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation GBM S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation HNSCC S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation LSCC S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation LUAD S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation OV S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation PDAC S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation UCEC S125 S128 S129 T135 S150 S155 S159 S160 S174 T189 S206 S237 S246 S273 S284 S304 S306 S314 T340 S343 S345 S346 S348 T350 T354 S355 S360 S361 S363 S369 S376 S378 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S125
S128
S129
T135
S150
S155
S159
S160
S174
T189
S206
S237
S246
S273
S284
S304
S306
S314
T340
S343
S345
S346
S348
T350
T354
S355
S360
S361
S363
S369
S376
S378
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S125
S128
S129
T135
S150
S155
S159
S160
S174
T189
S206
S237
S246
S273
S284
S304
S306
S314
T340
S343
S345
S346
S348
T350
T354
S355
S360
S361
S363
S369
S376
S378
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.