Protein: ENSP00000359484
Gene: SMAP1

LinkedOmicsKB © 2022-2023 Zhang Lab

SMAP1:
small ArfGAP 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S72VHISRVKSVNLDQWT459------17---101044----122
S151APLQPLVSSPSLQAA3756-3019------1010--------
S152PLQPLVSSPSLQAAV920417-1210--53-2213541083-105239
T206QLEPKKSTSPKKAAE19--54----------------
S207LEPKKSTSPKKAAEP19--54----------------
Showing 1 to 5 of 5 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S72VHISRVKSVNLDQWT-----------
S151APLQPLVSSPSLQAA-0.52--0.52--------
S152PLQPLVSSPSLQAAV-7.4e-6-----7.4e-6-----
T206QLEPKKSTSPKKAAE-----------
S207LEPKKSTSPKKAAEP-----------
Showing 1 to 5 of 5 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_JNK1/MAPK8S1529.8e-4---0.05-----6.9e-3
cibersort: NK cell activatedS1516.4e-3-0.18---0.012----
KINASE-PSP_P38A/MAPK14S726.8e-3---0.3-1---5.3e-3
cibersort: T cell CD4+ memory activatedS1510.015-0.4---9.6e-3----
HALLMARK_SPERMATOGENESISS1520.0160.34-0.68-1.9e-5-2.4e-3-2.7e-3--0.470.022
xcell: T cell CD8+S1510.017--0.91---4.7e-4----
KINASE-PSP_CDK5S1520.017---1.1e-30.91---0.560.41
TP53 mutationS1520.024---0.024------
xcell: stroma scoreS720.031---0.66--1---9.1e-3
SBS7b (UVR)S1520.0310.56---0.14----0.098
Showing 1 to 10 of 1290 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS72S151S152T206S207proteinRNASCNVmethylationCCRCCS72S151S152T206S207proteinRNASCNVmethylationCOADS72S151S152T206S207proteinRNASCNVmethylationGBMS72S151S152T206S207proteinRNASCNVmethylationHNSCCS72S151S152T206S207proteinRNASCNVmethylationLSCCS72S151S152T206S207proteinRNASCNVmethylationLUADS72S151S152T206S207proteinRNASCNVmethylationOVS72S151S152T206S207proteinRNASCNVmethylationPDACS72S151S152T206S207proteinRNASCNVmethylationUCECS72S151S152T206S207proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
CTDSPLS152-4.8e-6--0.04---1.4e-3-----7.6e-3
PPIP5K2S152-3.0e-5-0.2-0.12--9.2e-3-0.68--0.41--0.22-1.7e-3
PTPN6S152-2.6e-4-0.0560.99--2.9e-4-0.92--0.031--0.15-0.64
SACM1LS152-0.001-0.031-0.34--0.36-5.5e-3-0.28--0.039-0.37
PPM1MS152-1.8e-3-0.13---2.5e-3---0.014--0.46
PTPRCS152-1.8e-3-0.1-0.94--1.7e-3-0.69--0.86--0.024-0.55
FIG4S152-2.4e-3-0.41-0.043--0.840.47--0.2--0.08-7.6e-3
PTPRZ1S151-5.6e-3------5.6e-3----
SGPP1S152-7.1e-3-0.028-0.1-0.71-0.51--0.43--0.1-0.54
PTPN12S152-7.6e-3-0.048-0.78--2.8e-50.28--0.47--0.120.56
Showing 1 to 10 of 1200 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.