HSP90AB1: heat shock protein 90 alpha family class B member 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1qz2 chain G
1qz2 chain H
1uym chain A
2l6j chain B
3fwv chain C
3fwv chain D
3nmq chain A
3pry chain A
3pry chain B
3pry chain C
3uq3 chain B
3uq3 chain C
5fwk chain A
5fwk chain B
5fwl chain A
5fwl chain B
5fwm chain A
5fwm chain B
5fwp chain A
5fwp chain B
5uc4 chain A
5uc4 chain B
5uc4 chain C
5uc4 chain D
5uch chain A
5uch chain B
5uch chain C
5uch chain D
5uci chain A
5uci chain B
5uci chain C
5uci chain D
5ucj chain A
5ucj chain B
5ucj chain C
5ucj chain D
6n8w chain A
6n8w chain B
6n8w chain C
6n8w chain D
6n8y chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S206 KEVVKKHS QFIGYPI 1 9 - - - - - - 9 - - - - - - - - - - - - - S226 KEREKEIS DDEAEEE 10 1553 122 - 103 80 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S255 PKIEDVGS DEEDDSG 10 1553 122 - 103 80 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S261 GSDEEDDS GKDKKKK 9 993 113 - - - 17 10 99 - 108 62 108 99 110 101 7 1 105 44 7 2 Y301 DDITQEEY GEFYKSL 1 9 - - - - - - 9 - - - - - - - - - - - - - S365 RRVFIMDS CDELIPE 1 26 - - - - - - 26 - - - - - - - - - - - - - S417 KKCLELFS ELAEDKE 2 15 7 - - - - - - - - - 4 4 - - - - - - - - S434 KKFYEAFS KNLKLGI 3 24 - - - - - - - - 5 4 - - - - 5 3 5 2 - - S445 KLGIHEDS TNRRRLS 10 1370 122 - 99 76 58 58 99 - 88 54 108 99 110 101 68 17 86 34 78 15 S452 STNRRRLS ELLRYHT 6 223 - - 8 8 - - 18 - 61 37 25 23 9 9 - - 17 8 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S206 KEVVKKHS QFIGYPI - - - - - - - - - - - S226 KEREKEIS DDEAEEE 3e-42 - 0.013 0.024 - 3.2e-16 6.9e-33 1.3e-31 0.012 -0.33 0.66 S255 PKIEDVGS DEEDDSG 1.7e-51 - 4.2e-5 1.2e-8 - 8.4e-14 1.4e-30 2.4e-21 0.016 0.69 0.097 S261 GSDEEDDS GKDKKKK 6.5e-35 - - - - 1.8e-8 6.1e-27 1.4e-22 - -0.13 - Y301 DDITQEEY GEFYKSL - - - - - - - - - - - S365 RRVFIMDS CDELIPE - - - - - - - - - - - S417 KKCLELFS ELAEDKE - - - - - - - - - - - S434 KKFYEAFS KNLKLGI - - - - - - - - - - - S445 KLGIHEDS TNRRRLS 1.2e-49 - -0.5 4.3e-10 - 3.1e-5 4.9e-31 1.3e-15 0.028 6.8e-10 2.4e-5 S452 STNRRRLS ELLRYHT 0.013 - - - - 0.062 0.099 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S206
S226
S255
S261
Y301
S365
S417
S434
S445
S452
S460
S482
Y484
S532
S586
S587
S594
Y596
S615
T616
S718
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation CCRCC S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation COAD S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation GBM S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation HNSCC S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation LSCC S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation LUAD S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation OV S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation PDAC S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation UCEC S206 S226 S255 S261 Y301 S365 S417 S434 S445 S452 S460 S482 Y484 S532 S586 S587 S594 Y596 S615 T616 S718 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S206
S226
S255
S261
Y301
S365
S417
S434
S445
S452
S460
S482
Y484
S532
S586
S587
S594
Y596
S615
T616
S718
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S206
S226
S255
S261
Y301
S365
S417
S434
S445
S452
S460
S482
Y484
S532
S586
S587
S594
Y596
S615
T616
S718
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.