EPS15: epidermal growth factor receptor pathway substrate 15
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1c07 chain A
1eh2 chain A
1f8h chain A
1ff1 chain A
2iv9 chain P
2jxc chain A
4rh5 chain B
4rh9 chain B
4rhg chain B
4s0g chain B
5awt chain B
5awu chain B
5jp2 chain E
5jp2 chain F
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S108 PRFHDTSS PLLISGT 7 1011 - - 99 76 - - 99 - 108 62 103 94 102 92 - - 105 44 15 12 S140 DAIFDSLS PVNGFLS 7 1007 - - 95 80 - - 81 - 95 56 103 95 110 101 - - 102 42 35 12 S221 KRKTWVVS PAEKAKY 7 1030 - - 89 68 - - 99 - 96 55 98 90 101 93 - - 100 43 82 16 S324 QKNIIGSS PVADFSA 7 1132 - - 103 80 - - 99 - 108 62 108 99 110 101 - - 105 44 95 18 S368 DTIKQRTS EVQDLQD 1 8 - - - - - - - - - - - - 4 4 - - - - - - S467 ETAELEES VESGKAQ 4 136 8 - - - - - - - 11 5 19 18 40 35 - - - - - - S470 ELEESVES GKAQLEP 5 71 6 - - - - - - - 11 5 5 5 13 11 - - - - 15 - S485 LQQHLQDS QQEISSM 9 653 31 - 45 26 - - 37 - 75 42 69 64 88 81 6 2 39 16 30 2 S491 DSQQEISS MQMKLME 1 9 - - - - - - - - - - - - 5 4 - - - - - - S562 HQESPARS SPELLPS 2 18 - - - - - - - - 5 4 - - 4 5 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S108 PRFHDTSS PLLISGT -2.7e-33 - -3.5e-4 - - -8.4e-21 -1.3e-15 -2.7e-7 - -0.41 - S140 DAIFDSLS PVNGFLS -1.4e-9 - -6.0e-5 - - -4.0e-6 -0.2 0.8 - -1.8e-5 -0.38 S221 KRKTWVVS PAEKAKY -0.039 - -0.54 - - 3.4e-5 -2.1e-5 -3.3e-3 - -3.8e-3 0.14 S324 QKNIIGSS PVADFSA -2.9e-33 - -4.2e-5 - - -6.4e-19 -4.4e-18 -1.4e-10 - -1.6e-3 0.073 S368 DTIKQRTS EVQDLQD - - - - - - - - - - - S467 ETAELEES VESGKAQ -0.92 - - - - - - -0.92 - - - S470 ELEESVES GKAQLEP - - - - - - - - - - - S485 LQQHLQDS QQEISSM -1.6e-7 - 8.2e-3 - - -0.072 -2.5e-17 -2.5e-19 - 1.0e-6 - S491 DSQQEISS MQMKLME - - - - - - - - - - - S562 HQESPARS SPELLPS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S108
S140
S221
S324
S368
S467
S470
S485
S491
S562
S563
S595
T615
S622
S650
S655
T663
S669
T671
S675
S680
S681
S684
S713
S741
S746
T760
S761
S764
T777
S790
S796
S814
T828
Y849
S851
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation CCRCC S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation COAD S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation GBM S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation HNSCC S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation LSCC S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation LUAD S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation OV S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation PDAC S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation UCEC S108 S140 S221 S324 S368 S467 S470 S485 S491 S562 S563 S595 T615 S622 S650 S655 T663 S669 T671 S675 S680 S681 S684 S713 S741 S746 T760 S761 S764 T777 S790 S796 S814 T828 Y849 S851 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S108
S140
S221
S324
S368
S467
S470
S485
S491
S562
S563
S595
T615
S622
S650
S655
T663
S669
T671
S675
S680
S681
S684
S713
S741
S746
T760
S761
S764
T777
S790
S796
S814
T828
Y849
S851
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S108
S140
S221
S324
S368
S467
S470
S485
S491
S562
S563
S595
T615
S622
S650
S655
T663
S669
T671
S675
S680
S681
S684
S713
S741
S746
T760
S761
S764
T777
S790
S796
S814
T828
Y849
S851
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.