- VAV2:
- vav guanine nucleotide exchange factor 2
Lollipop plot
Phosphosites location and occurrence
Structure
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Site
| Sequence | Cohorts | Total | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N |
S91 | DKFGLRNSELFDPFD | 5 | 121 | - | - | 45 | 32 | - | - | 9 | - | 12 | 5 | 5 | 4 | 4 | 5 | - | - | - | - | - | - |
Y142 | TENDDDVYRSLEELA | 1 | 9 | - | - | - | - | - | - | 9 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Y159 | HDLGEDIYDCVPCED | 1 | 8 | - | - | 4 | 4 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
S392 | KISEFQSSIENLQVK | 5 | 293 | - | - | 16 | 16 | - | - | 54 | - | - | - | 28 | 26 | 41 | 36 | - | - | - | - | 69 | 7 |
S576 | IPPCKFTSPADLDAS | 7 | 464 | - | - | 49 | 40 | - | - | 44 | - | 75 | 42 | 15 | 13 | 28 | 23 | - | - | 66 | 28 | 34 | 7 |
S583 | SPADLDASGAGPGPK | 4 | 178 | - | - | 4 | 4 | - | - | 9 | - | - | - | 15 | 13 | 68 | 65 | - | - | - | - | - | - |
S626 | LLRGDPESPWWEGRL | 1 | 17 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 13 | 4 |
S639 | RLVQTRKSGYFPSSS | 4 | 55 | - | - | 4 | 4 | - | - | - | - | 7 | 3 | - | - | - | - | - | - | 5 | 3 | 25 | 4 |
S659 | VDGRPPISRPPSREI | 1 | 9 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 7 | 2 |
S663 | PPISRPPSREIDYTA | 7 | 595 | - | - | 99 | 76 | - | - | 55 | - | 95 | 56 | 25 | 22 | 31 | 27 | - | - | 53 | 22 | 23 | 11 |
Tumor and normal comparison
Site
| Sequence | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
---|---|---|---|---|---|---|---|---|---|---|---|---|
S91 | DKFGLRNSELFDPFD | 1.2e-6 | - | 1.2e-6 | - | - | - | - | - | - | - | - |
Y142 | TENDDDVYRSLEELA | - | - | - | - | - | - | - | - | - | - | - |
Y159 | HDLGEDIYDCVPCED | - | - | - | - | - | - | - | - | - | - | - |
S392 | KISEFQSSIENLQVK | 2.4e-4 | - | - | - | - | - | 0.61 | 2.7e-6 | - | - | - |
S576 | IPPCKFTSPADLDAS | 0.87 | - | -4.8e-4 | - | - | 1.1e-7 | - | 0.08 | - | -1.2e-3 | - |
S583 | SPADLDASGAGPGPK | -2.7e-20 | - | - | - | - | - | - | -2.7e-20 | - | - | - |
S626 | LLRGDPESPWWEGRL | - | - | - | - | - | - | - | - | - | - | - |
S639 | RLVQTRKSGYFPSSS | - | - | - | - | - | - | - | - | - | - | - |
S659 | VDGRPPISRPPSREI | - | - | - | - | - | - | - | - | - | - | - |
S663 | PPISRPPSREIDYTA | -1.7e-5 | - | -8.5e-8 | - | - | 2e-7 | -0.05 | -0.12 | - | -5.5e-7 | -0.065 |
Phenotype and mutation association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
PROGENy: PI3K | S576 | 1.3e-6 | - | 0.15 | - | 0.6 | 7.7e-6 | -0.76 | 0.055 | - | 8.6e-4 | 0.16 |
HALLMARK_ESTROGEN_RESPONSE_EARLY | S663 | 1.7e-6 | - | 5.9e-4 | - | 3.5e-3 | 0.048 | 0.53 | 0.32 | - | 0.075 | 0.35 |
PERT-PSP_NOCODAZOLE | S576 | 2.6e-6 | - | -0.93 | - | 0.53 | 0.031 | 0.63 | 0.005 | - | 1.4e-5 | 0.035 |
PROGENy: EGFR | S576 | 3.3e-6 | - | 0.73 | - | 0.072 | 1.2e-6 | -0.37 | 0.012 | - | 0.091 | 0.047 |
HALLMARK_DNA_REPAIR | S576 | 1.6e-5 | - | 0.21 | - | 0.37 | 3.3e-3 | 0.71 | 0.25 | - | 1.3e-4 | 0.32 |
HALLMARK_E2F_TARGETS | S576 | 2.1e-5 | - | 0.051 | - | -0.54 | 0.35 | 0.78 | 0.012 | - | 1.3e-5 | 0.065 |
HALLMARK_COAGULATION | S663 | 2.5e-5 | - | 0.25 | - | 2.5e-3 | 1.3e-3 | 0.19 | 0.71 | - | 0.091 | 0.7 |
HALLMARK_MYC_TARGETS_V2 | S576 | 2.8e-5 | - | 0.029 | - | 0.78 | 0.043 | -0.92 | 0.079 | - | 2.7e-4 | 0.2 |
HALLMARK_ESTROGEN_RESPONSE_LATE | S663 | 2.9e-5 | - | 0.029 | - | 9.2e-4 | 0.3 | -0.88 | 0.29 | - | 0.3 | 9.5e-3 |
HALLMARK_G2M_CHECKPOINT | S576 | 3.0e-5 | - | 0.059 | - | -0.52 | 0.63 | 0.64 | 0.015 | - | 5.0e-6 | 0.065 |
Cis-association
Kinase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Phosphatase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |