PREX1: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3qik chain A
4yon chain A
5d27 chain A
5d3v chain A
5d3v chain B
5d3w chain A
5d3w chain B
5d3x chain A
5d3x chain B
5d3y chain A
5d3y chain B
5fi0 chain A
5fi0 chain C
5fi0 chain E
5fi0 chain G
5fi1 chain A
6pcv chain A
6vsk chain A
7rx9 chain A
7syf chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S32 PGAAAPSS GPGPCAA 1 9 - - - - - - 9 - - - - - - - - - - - - - S43 PCAAARES ERQLRLR 1 18 - - - - - - 18 - - - - - - - - - - - - - S235 QAMKTVCS NINETKR 5 208 56 - - - - - 45 - - - 39 36 9 8 - - - - 12 3 S319 KSTKRTKS INGSLYI 9 582 29 - - - 6 3 99 - 31 16 55 48 14 12 41 10 92 38 70 18 S436 KDRRRKLS TVPKCFL 5 259 - - - - 17 28 99 - - - - - - - 27 7 29 14 31 7 S480 NGIIHHVS DKHQFKN 2 17 - - - - - - 9 - - - - - 4 4 - - - - - - S512 SELEDIMS KGVRLYC 2 30 - - - - - - - - - - - - - - 20 4 4 2 - - S523 RLYCRLHS LYTPVIK 2 47 - - - - - - 37 - - - 5 5 - - - - - - - - S834 LSLGPRLS LCEDSPM 4 160 46 - - - - - 69 - 5 2 20 18 - - - - - - - - S991 TTPSVGRS FSIRFGR 2 38 29 - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S32 PGAAAPSS GPGPCAA - - - - - - - - - - - S43 PCAAARES ERQLRLR - - - - - - - - - - - S235 QAMKTVCS NINETKR 2e-7 - - - - - 2e-7 - - - - S319 KSTKRTKS INGSLYI 0.082 - - - - 0.47 -0.095 - 2.9e-3 3.3e-9 -4.9e-5 S436 KDRRRKLS TVPKCFL -0.46 - - - - - - - - -0.46 - S480 NGIIHHVS DKHQFKN - - - - - - - - - - - S512 SELEDIMS KGVRLYC - - - - - - - - - - - S523 RLYCRLHS LYTPVIK - - - - - - - - - - - S834 LSLGPRLS LCEDSPM -0.044 - - - - - -0.044 - - - - S991 TTPSVGRS FSIRFGR - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S32
S43
S235
S319
S436
S480
S512
S523
S834
S991
S1001
S1049
S1112
S1115
S1119
S1126
S1139
S1159
T1163
S1165
Y1166
S1179
S1182
S1185
S1190
S1191
Y1192
S1195
S1200
S1256
S1272
S1277
S1480
S1483
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation CCRCC S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation COAD S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation GBM S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation HNSCC S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation LSCC S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation LUAD S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation OV S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation PDAC S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation UCEC S32 S43 S235 S319 S436 S480 S512 S523 S834 S991 S1001 S1049 S1112 S1115 S1119 S1126 S1139 S1159 T1163 S1165 Y1166 S1179 S1182 S1185 S1190 S1191 Y1192 S1195 S1200 S1256 S1272 S1277 S1480 S1483 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S32
S43
S235
S319
S436
S480
S512
S523
S834
S991
S1001
S1049
S1112
S1115
S1119
S1126
S1139
S1159
T1163
S1165
Y1166
S1179
S1182
S1185
S1190
S1191
Y1192
S1195
S1200
S1256
S1272
S1277
S1480
S1483
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S32
S43
S235
S319
S436
S480
S512
S523
S834
S991
S1001
S1049
S1112
S1115
S1119
S1126
S1139
S1159
T1163
S1165
Y1166
S1179
S1182
S1185
S1190
S1191
Y1192
S1195
S1200
S1256
S1272
S1277
S1480
S1483
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.