IRS4: insulin receptor substrate 4
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S66 ATGSRSDS ESEEEDL 2 16 - - - - - - - - 5 3 5 3 - - - - - - - - S68 GSRSDSES EEEDLPV 2 53 - - - - - - - - 5 3 25 20 - - - - - - - - S403 TRRFVTPS EPVAHSR 1 18 - - - - - - - - - - 10 8 - - - - - - - - S409 PSEPVAHS RRGRLHL 1 10 - - - - - - - - - - 5 5 - - - - - - - - S427 RRSRRAVS VPASFFR 2 46 - - - - - - - - 5 3 20 18 - - - - - - - - S439 FFRRLAPS PARPRHP 3 95 6 - - - - - - - - - 45 35 - - 7 2 - - - - S465 SEVSGSGS GNFGEEG 1 9 - - - - - - - - - - 5 4 - - - - - - - - S600 GSGSGKGS DGDGERG 1 9 - - - - - - - - - - 5 4 - - - - - - - - Y700 DEDEDDPY VPMRPGV 1 19 - - - - - - - - - - 10 9 - - - - - - - - S735 SKKRHSRS PFEDSRG 1 9 - - - - - - - - - - 5 4 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S66 ATGSRSDS ESEEEDL - - - - - - - - - - - S68 GSRSDSES EEEDLPV 1.2e-5 - - - - - 1.2e-5 - - - - S403 TRRFVTPS EPVAHSR - - - - - - - - - - - S409 PSEPVAHS RRGRLHL - - - - - - - - - - - S427 RRSRRAVS VPASFFR 0.2 - - - - - 0.2 - - - - S439 FFRRLAPS PARPRHP 7.2e-5 - - - - - 7.2e-5 - - - - S465 SEVSGSGS GNFGEEG - - - - - - - - - - - S600 GSGSGKGS DGDGERG - - - - - - - - - - - Y700 DEDEDDPY VPMRPGV - - - - - - - - - - - S735 SKKRHSRS PFEDSRG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S66
S68
S403
S409
S427
S439
S465
S600
Y700
S735
Y743
S751
S757
S775
S777
Y779
S804
S818
Y828
S859
S863
S893
Y921
S931
T1042
S1089
S1091
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation CCRCC S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation COAD S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation GBM S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation HNSCC S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation LSCC S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation LUAD S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation OV S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation PDAC S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation UCEC S66 S68 S403 S409 S427 S439 S465 S600 Y700 S735 Y743 S751 S757 S775 S777 Y779 S804 S818 Y828 S859 S863 S893 Y921 S931 T1042 S1089 S1091 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S66
S68
S403
S409
S427
S439
S465
S600
Y700
S735
Y743
S751
S757
S775
S777
Y779
S804
S818
Y828
S859
S863
S893
Y921
S931
T1042
S1089
S1091
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S66
S68
S403
S409
S427
S439
S465
S600
Y700
S735
Y743
S751
S757
S775
S777
Y779
S804
S818
Y828
S859
S863
S893
Y921
S931
T1042
S1089
S1091
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.