RAPGEF1: Rap guanine nucleotide exchange factor 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S12 SQRSHLSS FTMKLMD 2 61 - - - - - - 27 - - - - - 18 16 - - - - - - S40 KGKPAEVS VKIPEKP 1 30 - - 19 11 - - - - - - - - - - - - - - - - S91 SQRQKNLS WLEEKEK 3 116 - - 8 - - - - - - - 5 4 52 47 - - - - - - S214 IEKQGRPS PTSPVKP 7 606 - - 38 36 - - 55 - 104 58 30 28 26 24 - - 97 40 68 2 T216 KQGRPSPT SPVKPSS 5 150 - - 21 19 - - - - 41 22 15 14 4 3 - - 8 3 - - S217 QGRPSPTS PVKPSSP 6 166 - - 4 4 - - 27 - 13 6 - - 9 8 - - 22 11 53 9 S223 TSPVKPSS PASKPDG 1 9 - - - - - - 9 - - - - - - - - - - - - - S251 LNKTTGMS QSTELLP 1 8 - - 4 4 - - - - - - - - - - - - - - - - S253 KTTGMSQS TELLPDA 7 275 - - 12 12 - - 52 - 18 9 35 31 30 29 - - 19 6 19 3 T254 TTGMSQST ELLPDAT 6 368 - - 47 44 - - - - 69 41 19 18 31 28 - - 17 9 38 7
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S12 SQRSHLSS FTMKLMD - - - - - - - - - - - S40 KGKPAEVS VKIPEKP - - - - - - - - - - - S91 SQRQKNLS WLEEKEK -1e-15 - - - - - - -1e-15 - - - S214 IEKQGRPS PTSPVKP 7e-8 - 4.1e-3 - - 4.7e-8 0.27 0.72 - 0.024 - T216 KQGRPSPT SPVKPSS 1.5e-5 - 8.3e-5 - - 0.029 - - - - - S217 QGRPSPTS PVKPSSP -9.5e-3 - - - - - - - - -9.5e-3 - S223 TSPVKPSS PASKPDG - - - - - - - - - - - S251 LNKTTGMS QSTELLP - - - - - - - - - - - S253 KTTGMSQS TELLPDA -1.4e-4 - - - - - -3.7e-4 -0.07 - - - T254 TTGMSQST ELLPDAT 0.83 - 6.4e-14 - - -2.3e-3 - -1.5e-6 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S12
S40
S91
S214
T216
S217
S223
S251
S253
T254
T261
S281
S293
S296
S311
S313
S314
S335
S338
S340
Y341
S345
S349
S353
S358
S360
S365
S366
S371
S375
S463
S466
S477
S601
S646
S652
S658
T819
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation CCRCC S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation COAD S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation GBM S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation HNSCC S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation LSCC S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation LUAD S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation OV S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation PDAC S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation UCEC S12 S40 S91 S214 T216 S217 S223 S251 S253 T254 T261 S281 S293 S296 S311 S313 S314 S335 S338 S340 Y341 S345 S349 S353 S358 S360 S365 S366 S371 S375 S463 S466 S477 S601 S646 S652 S658 T819 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S12
S40
S91
S214
T216
S217
S223
S251
S253
T254
T261
S281
S293
S296
S311
S313
S314
S335
S338
S340
Y341
S345
S349
S353
S358
S360
S365
S366
S371
S375
S463
S466
S477
S601
S646
S652
S658
T819
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S12
S40
S91
S214
T216
S217
S223
S251
S253
T254
T261
S281
S293
S296
S311
S313
S314
S335
S338
S340
Y341
S345
S349
S353
S358
S360
S365
S366
S371
S375
S463
S466
S477
S601
S646
S652
S658
T819
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.