Protein: ENSP00000361275

PLK3:: polo like kinase 3

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S551	MKGGDLPSVEEVEVP	1	60	-	-	-	-	-	-	-	-	38	22	-	-	-	-	-	-	-	-	-	-

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Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S551	MKGGDLPSVEEVEVP	-5.5e-4	-	-	-	-	-5.5e-4	-	-	-	-	-

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* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
PROGENy: p53	S551	1.5e-4	-	-	-	-	1.5e-4	-	-	-	-	-
xcell: Monocyte	S551	2.9e-3	-	-	-	-	2.9e-3	-	-	-	-	-
HALLMARK_P53_PATHWAY	S551	3.4e-3	-	-	-	-	3.4e-3	-	-	-	-	-
PERT-PSP_INSULIN	S551	9.5e-3	-	-	-	-	9.5e-3	-	-	-	-	-
PERT-PSP_EGF	S551	9.7e-3	-	-	-	-	9.7e-3	-	-	-	-	-
PROGENy: WNT	S551	0.012	-	-	-	-	0.012	-	-	-	-	-
xcell: T cell CD8+	S551	0.015	-	-	-	-	0.015	-	-	-	-	-
xcell: Mast cell	S551	0.016	-	-	-	-	0.016	-	-	-	-	-
HALLMARK_KRAS_SIGNALING_DN	S551	0.018	-	-	-	-	0.018	-	-	-	-	-
xcell: Eosinophil	S551	0.019	-	-	-	-	0.019	-	-	-	-	-

Showing 1 to 10 of 258 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
GAK	S551	3.8e-4	-	-	-	-	3.8e-4	-	-	-	-	-
MAP3K6	S551	0.002	-	-	-	-	0.002	-	-	-	-	-
RPS6KA4	S551	2.3e-3	-	-	-	-	2.3e-3	-	-	-	-	-
GRK3	S551	2.6e-3	-	-	-	-	2.6e-3	-	-	-	-	-
TNK2	S551	4.3e-3	-	-	-	-	4.3e-3	-	-	-	-	-
RIOK3	S551	4.5e-3	-	-	-	-	4.5e-3	-	-	-	-	-
PTK6	S551	4.6e-3	-	-	-	-	4.6e-3	-	-	-	-	-
SLK	S551	5.4e-3	-	-	-	-	5.4e-3	-	-	-	-	-
PRKCH	S551	5.5e-3	-	-	-	-	5.5e-3	-	-	-	-	-
STK38L	S551	0.006	-	-	-	-	0.006	-	-	-	-	-

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* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
PTPN14	S551	-0.017	-	-	-	-	-0.017	-	-	-	-	-
PPM1G	S551	-0.027	-	-	-	-	-0.027	-	-	-	-	-
ILKAP	S551	-0.03	-	-	-	-	-0.03	-	-	-	-	-
MINPP1	S551	-0.032	-	-	-	-	-0.032	-	-	-	-	-
NANP	S551	-0.033	-	-	-	-	-0.033	-	-	-	-	-
NT5DC2	S551	-0.035	-	-	-	-	-0.035	-	-	-	-	-
OCRL	S551	-0.04	-	-	-	-	-0.04	-	-	-	-	-
EYA3	S551	-0.067	-	-	-	-	-0.067	-	-	-	-	-
NT5DC3	S551	-0.07	-	-	-	-	-0.07	-	-	-	-	-
CTDSPL	S551	-0.08	-	-	-	-	-0.08	-	-	-	-	-

Showing 1 to 10 of 240 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000361275Gene: PLK3

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000361275
Gene: PLK3