Protein: ENSP00000362352
Gene: MACROH2A2

LinkedOmicsKB © 2022-2023 Zhang Lab

MACROH2A2:
macroH2A.2 histone

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S129GKSETILSPPPEKRG101228104-7756373563-7445989010697831893399518
S171DSDKEGTSNSTSEDG220--------53--------12-
S173DKEGTSNSTSEDGPG7109--88729-64----14262365
T174KEGTSNSTSEDGPGD59416-1212----117------42264
S175EGTSNSTSEDGPGDG967980-95747118-321958542219--60279518
S190FTILSSKSLVLGQKL2126-----------------6-
S251TVKELRKSQGPLEVA4111--------1710232189----149
S342SAHFDDSSASSLKNV3417-----------98152----
Showing 1 to 8 of 8 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S129GKSETILSPPPEKRG-4e-8--6.6e-160.82--0.0160.14-2.7e-30.23-1.2e-120.031
S171DSDKEGTSNSTSEDG-----------
S173DKEGTSNSTSEDGPG-----------
T174KEGTSNSTSEDGPGD-----------
S175EGTSNSTSEDGPGDG-3.3e-8--2.3e-24---0.820.350.26--0.014-6.6e-3
S190FTILSSKSLVLGQKL-----------
S251TVKELRKSQGPLEVA9.2e-9-----9.2e-9----
S342SAHFDDSSASSLKNV-----------
Showing 1 to 8 of 8 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS129S171S173T174S175S190S251S342proteinRNASCNVmethylationCCRCCS129S171S173T174S175S190S251S342proteinRNASCNVmethylationCOADS129S171S173T174S175S190S251S342proteinRNASCNVmethylationGBMS129S171S173T174S175S190S251S342proteinRNASCNVmethylationHNSCCS129S171S173T174S175S190S251S342proteinRNASCNVmethylationLSCCS129S171S173T174S175S190S251S342proteinRNASCNVmethylationLUADS129S171S173T174S175S190S251S342proteinRNASCNVmethylationOVS129S171S173T174S175S190S251S342proteinRNASCNVmethylationPDACS129S171S173T174S175S190S251S342proteinRNASCNVmethylationUCECS129S171S173T174S175S190S251S342proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.