PLCG1: phospholipase C gamma 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1hsq chain A
2hsp chain A
4ey0 chain A
4ey0 chain B
4ey0 chain C
4ey0 chain D
4fbn chain A
7nxe chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S121 EFRLKTLS LQATSED 1 8 - - - - - - - - - - - - - - - - - - 6 2 S279 QVQEFMLS FLRDPLR 1 10 - - - - - - 10 - - - - - - - - - - - - - S451 ISADGLPS PNQLKRK 2 27 - - - - - - 17 - - - 5 5 - - - - - - - - Y472 KLAEGSAY EEVPTSM 1 9 - - - - - - 9 - - - - - - - - - - - - - Y481 EVPTSMMY SENDISN 1 8 - - - - - - - - - - - - - - - - - - 6 2 S482 VPTSMMYS ENDISNS 1 9 - - - - - - 9 - - - - - - - - - - - - - Y506 DPVNHEWY PHYFVLT 1 10 - - - - - - - - - - 5 5 - - - - - - - - S525 YYSEETSS DQGNEDE 10 1095 70 - 98 76 9 17 99 - 97 55 98 90 76 68 7 1 86 35 95 18 S540 EEPKEVSS STELHSN 1 9 - - - - - - 9 - - - - - - - - - - - - - Y771 IGTAEPDY GALYEGR 3 108 - - - - - - 80 - - - - - - - - - 5 3 11 9
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S121 EFRLKTLS LQATSED - - - - - - - - - - - S279 QVQEFMLS FLRDPLR - - - - - - - - - - - S451 ISADGLPS PNQLKRK - - - - - - - - - - - Y472 KLAEGSAY EEVPTSM - - - - - - - - - - - Y481 EVPTSMMY SENDISN - - - - - - - - - - - S482 VPTSMMYS ENDISNS - - - - - - - - - - - Y506 DPVNHEWY PHYFVLT - - - - - - - - - - - S525 YYSEETSS DQGNEDE -3.4e-13 - 1.4e-8 - - 0.098 -4.1e-25 -8.1e-14 - -5.2e-3 -5.7e-6 S540 EEPKEVSS STELHSN - - - - - - - - - - - Y771 IGTAEPDY GALYEGR - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S121
S279
S451
Y472
Y481
S482
Y506
S525
S540
Y771
Y783
S815
Y977
S1221
T1226
S1227
S1233
S1236
S1248
Y1253
S1263
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation CCRCC S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation COAD S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation GBM S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation HNSCC S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation LSCC S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation LUAD S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation OV S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation PDAC S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation UCEC S121 S279 S451 Y472 Y481 S482 Y506 S525 S540 Y771 Y783 S815 Y977 S1221 T1226 S1227 S1233 S1236 S1248 Y1253 S1263 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S121
S279
S451
Y472
Y481
S482
Y506
S525
S540
Y771
Y783
S815
Y977
S1221
T1226
S1227
S1233
S1236
S1248
Y1253
S1263
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S121
S279
S451
Y472
Y481
S482
Y506
S525
S540
Y771
Y783
S815
Y977
S1221
T1226
S1227
S1233
S1236
S1248
Y1253
S1263
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.