Protein: ENSP00000362649
Gene: HDAC1

LinkedOmicsKB © 2022-2023 Zhang Lab

HDAC1:
histone deacetylase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y13GTRRKVCYYYDGDVG19----------54--------
Y14TRRKVCYYYDGDVGN19----------54--------
Y15RRKVCYYYDGDVGNY19----------54--------
S117CQLSTGGSVASAVKL18--44----------------
S348FKLHISPSNMTNQNT4478-------------71421411
S393EDAIPEESGDEDEDD101497122-103809710099-10862103951101014312105449518
S406DDPDKRISICSSDKR91264122-9976--99-9755103951101013812102429518
S409DKRISICSSDKRIAC101263104-10380222354-10259103941101014513105448318
S410KRISICSSDKRIACE10108787-9472656118-633783751029227673279015
S421IACEEEFSDSEEEGE10144795-10380879273-1086210899106976015105449518
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y13GTRRKVCYYYDGDVG-----------
Y14TRRKVCYYYDGDVGN-----------
Y15RRKVCYYYDGDVGNY-----------
S117CQLSTGGSVASAVKL-----------
S348FKLHISPSNMTNQNT-----------
S393EDAIPEESGDEDEDD3e-19--0.0181.3e-14-0.0231.3e-261.4e-210.22-8.6e-50.8
S406DDPDKRISICSSDKR-2.9e-4--3.8e-10--0.42-0.0950.670.031-1.2e-80.51
S409DKRISICSSDKRIAC0.48--3.7e-97.2e-4-7.8e-96.0e-4-0.16-0.96-5.1e-40.79
S410KRISICSSDKRIACE8.8e-9--0.0191.5e-14-0.581.2e-113.6e-5--1.3e-30.1
S421IACEEEFSDSEEEGE1.1e-45--1.5e-108.8e-15-2.7e-199.6e-306.9e-200.180.0551.2e-9
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationCCRCCY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationCOADY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationGBMY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationHNSCCY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationLSCCY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationLUADY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationOVY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationPDACY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylationUCECY13Y14Y15S117S348S393S406S409S410S421S423S434S435T445proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.