SRC: SRC proto-oncogene, non-receptor tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1a07 chain A
1a07 chain B
1a08 chain A
1a08 chain B
1a09 chain A
1a09 chain B
1a1a chain A
1a1a chain B
1a1b chain A
1a1b chain B
1a1c chain A
1a1c chain B
1a1e chain A
1a1e chain B
1fmk chain A
1hcs chain B
1hct chain B
1ksw chain A
1o41 chain A
1o42 chain A
1o43 chain A
1o44 chain A
1o45 chain A
1o46 chain A
1o47 chain A
1o48 chain A
1o49 chain A
1o4a chain A
1o4b chain A
1o4c chain A
1o4d chain A
1o4e chain A
1o4f chain A
1o4g chain A
1o4h chain A
1o4i chain A
1o4j chain A
1o4k chain A
1o4l chain A
1o4m chain A
1o4n chain A
1o4o chain A
1o4p chain A
1o4q chain A
1o4r chain A
1shd chain A
1y57 chain A
1yi6 chain A
1yi6 chain B
1yoj chain A
1yoj chain B
1yol chain A
1yol chain B
1yom chain A
1yom chain B
2bdf chain A
2bdf chain B
2bdj chain A
2h8h chain A
2src chain A
3vro chain B
3zmp chain C
3zmp chain D
3zmq chain C
4f59 chain A
4f5a chain A
4f5b chain A
4hxj chain A
4hxj chain B
4k11 chain A
4mxo chain A
4mxo chain B
4mxx chain A
4mxx chain B
4mxy chain A
4mxy chain B
4mxz chain A
4mxz chain B
6ate chain A
6c4s chain A
6c4s chain B
6e6e chain A
6e6e chain B
6e6e chain C
6e6e chain D
6e6e chain E
6e6e chain F
6e6e chain G
6e6e chain H
7ng7 chain A
7ote chain A
7ote chain B
7t1u chain A
7t1u chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S17 DASQRRRS LEPAENV 10 1527 114 - 103 80 97 100 99 - 108 62 108 99 110 101 67 17 105 44 95 18 S35 GGGAFPAS QTPSKPA 4 59 9 - - - 11 15 - - - - - - 10 8 - - - - 6 - S51 ADGHRGPS AAFAPAA 2 17 - - - - - - - - 5 4 - - - - 7 1 - - - - S69 KLFGGFNS SDTVTSP 9 882 43 - 83 63 51 47 - - 97 55 65 58 56 52 69 17 54 23 36 13 S70 LFGGFNSS DTVTSPQ 6 142 8 - - - 4 5 - - 5 3 - - 19 17 6 1 - - 59 15 T74 FNSSDTVT SPQRAGP 2 18 - - - - - - 9 - - - - - - - - - - - - 9 S75 NSSDTVTS PQRAGPL 8 374 - - - - 29 25 71 - 5 3 5 4 4 4 49 10 52 19 76 18 S104 SRTETDLS FKKGERL 7 214 - - - - - - 9 - 10 7 30 26 43 40 5 3 23 12 6 - Y187 SETTKGAY CLSVSDF 3 62 - - - - - - 46 - - - 5 5 - - - - - - 6 - Y216 KLDSGGFY ITSRTQF 1 8 - - - - - - - - - - - - 4 4 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S17 DASQRRRS LEPAENV 0.49 - 5.6e-7 -0.43 - 2.4e-5 -0.017 -6.8e-6 -0.74 0.013 -0.077 S35 GGGAFPAS QTPSKPA - - - - - - - - - - - S51 ADGHRGPS AAFAPAA - - - - - - - - - - - S69 KLFGGFNS SDTVTSP 0.1 - -0.37 -0.048 - 7.8e-3 3.6e-5 -0.86 -0.85 0.41 0.8 S70 LFGGFNSS DTVTSPQ 0.25 - - - - - - - - - 0.25 T74 FNSSDTVT SPQRAGP - - - - - - - - - - - S75 NSSDTVTS PQRAGPL -1.4e-3 - - -0.019 - - - - -9.8e-5 0.23 -0.17 S104 SRTETDLS FKKGERL 7.2e-4 - - - - - 3.4e-6 -1.3e-4 - 4.7e-7 - Y187 SETTKGAY CLSVSDF - - - - - - - - - - - Y216 KLDSGGFY ITSRTQF - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S17
S35
S51
S69
S70
T74
S75
S104
Y187
Y216
Y530
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation CCRCC S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation COAD S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation GBM S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation HNSCC S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation LSCC S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation LUAD S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation OV S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation PDAC S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation UCEC S17 S35 S51 S69 S70 T74 S75 S104 Y187 Y216 Y530 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S17
S35
S51
S69
S70
T74
S75
S104
Y187
Y216
Y530
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S17
S35
S51
S69
S70
T74
S75
S104
Y187
Y216
Y530
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.