Protein: ENSP00000362727
Gene: DENND1A

LinkedOmicsKB © 2022-2023 Zhang Lab

DENND1A:
DENN domain containing 1A

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T24VEVAYPRTGGTLSDP219------9---55--------
S412LSTVRKGSGAILNTV5290------63---282745--66295414
S473QLPKTAPSPLVEAKD71094--10380--90-10862108999889--102429518
S510HVVKRPKSNIAVEGR865426-9168--72-513059541916--83323518
T519IAVEGRRTSVPSPEQ47215---------1081816--41--
S520AVEGRRTSVPSPEQP10116399-78579710062-905165607467831952227116
S523GRRTSVPSPEQPQPY10106775-5551949499-3220103945653681730139518
S536PYRTLRESDSAEGDE1072345-3524363573-10783769080367134609
S538RTLRESDSAEGDEAE1054822-5747369-6939797154495362189
S546AEGDEAESPEQQVRK10100963-9580889172-78446864464034758254115
Showing 1 to 10 of 24 rows
1025
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T24VEVAYPRTGGTLSDP-----------
S412LSTVRKGSGAILNTV-0.11------9.5e-3--2.5e-3-1.6e-3
S473QLPKTAPSPLVEAKD-1.2e-6-0.44--0.68-5.4e-15-3.4e-11-2.4e-4-0.022
S510HVVKRPKSNIAVEGR-2.0e-6-1.4e-6---0.058-3.1e-17--0.42-2.9e-9
T519IAVEGRRTSVPSPEQ-----------
S520AVEGRRTSVPSPEQP-3.0e-4-2.2e-5-8.9e-11--0.54-4.6e-4-0.43-0.150.15-0.002
S523GRRTSVPSPEQPQPY-0.11--5.8e-10-0.79-0.0610.630.450.530.87-0.048
S536PYRTLRESDSAEGDE-0.81--7.5e-5-0.45--0.552.8e-4---
S538RTLRESDSAEGDEAE-0.26--3.2e-7--3.8e-30.44-0.41---
S546AEGDEAESPEQQVRK0.75--6.3e-15-0.31-4.6e-31.1e-131.5e-4--1.4e-3-0.22
Showing 1 to 10 of 24 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationCCRCCT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationCOADT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationGBMT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationHNSCCT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationLSCCT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationLUADT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationOVT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationPDACT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylationUCECT24S412S473S510T519S520S523S536S538S546S554S567S592S619S640S650S656T691T707S883S891T923S986S988proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.