Protein: ENSP00000363371
Gene: CNKSR1

LinkedOmicsKB © 2022-2023 Zhang Lab

CNKSR1:
connector enhancer of kinase suppressor of Ras 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S22WLRGLDDSLQDYPFE18----------44--------
T289KKIPIPETPPQTPPQ8804105---7676--1015964581101017231104-
T293IPETPPQTPPQVLDS847424---45--36161414948328638128218
S300TPPQVLDSPHQRSPS84599---4139--402335295334671307816
S305LDSPHQRSPSLSLAP91070113-877469--45261089810292831980349418
S307SPHQRSPSLSLAPLS839433---54--291553474440447325414
S309HQRSPSLSLAPLSPR5539-------10744----73-9
S314SLSLAPLSPRAPSED9836105-333726--874893852523681588367816
S392KGLATRLSRRRVSCR988495-11114949--54349385968935787384011
T564PTQRSPRTSFGSLTD16------------------6-
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S22WLRGLDDSLQDYPFE-----------
T289KKIPIPETPPQTPPQ1.2e-4--0.12--0.230.0494.5e-4-5.8e-3-
T293IPETPPQTPPQVLDS0.022-----0.17--0.46-1.2e-35.6e-4
S300TPPQVLDSPHQRSPS0.038--0.85--0.460.1---0.811.5e-4
S305LDSPHQRSPSLSLAP4.9e-29--1e-9-0.0258.1e-141.9e-100.0430.658.5e-7
S307SPHQRSPSLSLAPLS-0.48----0.01-0.53-1.1e-5--0.29
S309HQRSPSLSLAPLSPR-----------
S314SLSLAPLSPRAPSED-0.18--0.049--2.3e-35.3e-4-0.0280.29-1e-100.094
S392KGLATRLSRRRVSCR-1.8e-4--1.5e-4--0.67-2.2e-13-1.9e-7--0.710.69
T564PTQRSPRTSFGSLTD-----------
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationCCRCCS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationCOADS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationGBMS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationHNSCCS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationLSCCS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationLUADS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationOVS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationPDACS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylationUCECS22T289T293S300S305S307S309S314S392T564S565S568T570S590proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.