- PTPN3:
- protein tyrosine phosphatase non-receptor type 3
Lollipop plot
Phosphosites location and occurrence
Structure
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Site
| Sequence | Cohorts | Total | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N |
S329 | SQYWTMGSRNTKKSV | 1 | 14 | - | - | 7 | 7 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
S335 | GSRNTKKSVNNQYCK | 9 | 693 | 17 | - | 22 | 20 | 14 | 21 | - | - | 71 | 39 | 68 | 63 | 56 | 50 | 26 | 8 | 81 | 30 | 89 | 18 |
S357 | WNPAMRRSLSVEHLE | 10 | 559 | 37 | - | 29 | 24 | 5 | 4 | 36 | - | 70 | 38 | 54 | 50 | 85 | 75 | 6 | 2 | 12 | 5 | 18 | 9 |
S359 | PAMRRSLSVEHLETK | 10 | 1416 | 122 | - | 95 | 73 | 75 | 77 | 54 | - | 108 | 62 | 103 | 95 | 105 | 97 | 83 | 19 | 105 | 44 | 81 | 18 |
S367 | VEHLETKSLPSRSPP | 8 | 480 | 53 | - | 28 | 27 | 10 | 8 | - | - | 15 | 10 | 63 | 59 | 53 | 48 | - | - | 4 | 1 | 83 | 18 |
S370 | LETKSLPSRSPPITP | 5 | 163 | 53 | - | 20 | 20 | - | - | - | - | 5 | 3 | 10 | 10 | 22 | 20 | - | - | - | - | - | - |
S372 | TKSLPSRSPPITPNW | 10 | 1301 | 71 | - | 103 | 80 | 70 | 64 | 17 | - | 95 | 56 | 108 | 99 | 106 | 98 | 83 | 19 | 87 | 38 | 89 | 18 |
T376 | PSRSPPITPNWRSPR | 8 | 360 | 18 | - | 5 | 4 | 19 | 16 | - | - | 5 | 3 | 40 | 34 | 54 | 48 | - | - | 5 | 2 | 89 | 18 |
S381 | PITPNWRSPRLRHEI | 7 | 429 | 52 | - | 60 | 56 | 4 | 5 | - | - | - | - | 30 | 27 | 50 | 44 | - | - | 50 | 21 | 16 | 14 |
S394 | EIRKPRHSSADNLAN | 6 | 190 | 8 | - | 4 | 4 | 40 | 40 | - | - | 6 | 3 | 35 | 32 | 10 | 8 | - | - | - | - | - | - |
Tumor and normal comparison
Site
| Sequence | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
---|---|---|---|---|---|---|---|---|---|---|---|---|
S329 | SQYWTMGSRNTKKSV | - | - | - | - | - | - | - | - | - | - | - |
S335 | GSRNTKKSVNNQYCK | 8.9e-9 | - | 0.013 | - | - | -0.17 | 0.9 | 1.3e-10 | - | 2.9e-6 | 0.08 |
S357 | WNPAMRRSLSVEHLE | -0.68 | - | 2.1e-3 | - | - | -0.77 | -9.8e-7 | 0.19 | - | - | - |
S359 | PAMRRSLSVEHLETK | -0.093 | - | -3.9e-18 | 1.3e-7 | - | -4.2e-3 | 0.35 | 8.3e-4 | 1.2e-4 | -0.95 | 0.013 |
S367 | VEHLETKSLPSRSPP | 1.2e-6 | - | -0.73 | - | - | - | 8.9e-8 | 1.2e-3 | - | - | 0.15 |
S370 | LETKSLPSRSPPITP | 0.1 | - | 0.31 | - | - | - | - | 0.2 | - | - | - |
S372 | TKSLPSRSPPITPNW | -0.19 | - | -4e-11 | -0.83 | - | -3.8e-5 | -1.7e-3 | 0.016 | -0.96 | 9.4e-5 | 3.3e-5 |
T376 | PSRSPPITPNWRSPR | 1.3e-7 | - | - | - | - | - | 0.43 | 1.9e-5 | - | - | 4.7e-5 |
S381 | PITPNWRSPRLRHEI | -1.7e-6 | - | -2.9e-13 | - | - | - | 0.23 | -0.9 | - | -7.9e-4 | - |
S394 | EIRKPRHSSADNLAN | -0.27 | - | - | -0.79 | - | - | -0.2 | - | - | - | - |
Phenotype and mutation association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Cis-association
Kinase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Phosphatase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |