Protein: ENSP00000363944
Gene: LAS1L

LinkedOmicsKB © 2022-2023 Zhang Lab

LAS1L:
LAS1 like ribosome biogenesis factor

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S235EPQDDGKSTESDVKA869862-7456--63-543373684944--46204214
T236PQDDGKSTESDVKAD837649-5739--18-3418543129--3110429
S238DDGKSTESDVKADGD1097274-44705672-402593856660681694409015
S246DVKADGDSKGSEEVD9110370-103807218-101591089910292--105449518
S249ADGDSKGSEEVDSHC1076173-4129161136-3926746871637173328318
S441GRNARRFSAGQWEAR931040-44--81-732019312820551375
S514YTQSGENSLVQEGSE372----------151598----1213
S520NSLVQEGSEASPIGK35932---------5598------
S523VQEGSEASPIGKSPY105109-1716342990-23141918272419337189518
S528EASPIGKSPYTLDSL5220--88----372529272220----2816
Showing 1 to 10 of 17 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S235EPQDDGKSTESDVKA7.8e-17--0.021--5.4e-41.3e-213e-20--7.4e-31.6e-3
T236PQDDGKSTESDVKAD-7.9e-4--3.5e-5---0.93-6.2e-3--1.7e-7-
S238DDGKSTESDVKADGD0.066--1.9e-10--0.642.2e-50.180.13-1.1e-10-0.1
S246DVKADGDSKGSEEVD-0.72--6.4e-22--6.5e-30.0294.5e-5--0.57-0.27
S249ADGDSKGSEEVDSHC5.9e-4--2.7e-6--2.6e-41.6e-71.9e-5--0.580.63
S441GRNARRFSAGQWEAR0.74------0.860.52---
S514YTQSGENSLVQEGSE-----------
S520NSLVQEGSEASPIGK-----------
S523VQEGSEASPIGKSPY0.13--1.0e-5-0.65-0.25--0.23-0.16
S528EASPIGKSPYTLDSL5.6e-4-----0.60.020.023--4.7e-3
Showing 1 to 10 of 17 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationCCRCCS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationCOADS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationGBMS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationHNSCCS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationLSCCS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationLUADS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationOVS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationPDACS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylationUCECS235T236S238S246S249S441S514S520S523S528S545S560S612T613S617T619S641proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.