Protein: ENSP00000364119
Gene: EIF2S2

LinkedOmicsKB © 2022-2023 Zhang Lab

EIF2S2:
eukaryotic translation initiation factor 2 subunit beta

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S2______MSGDEMIFD952360-1716--62-462868622624286325718
T33DEEGDTQTEETQPSE620748-3618--9---393644----112
T36GDTQTEETQPSETKE166-------------------
S39QTEETQPSETKEVEP620433-1311------29251212--44196-
T61LEADEEDTRKKDASD721655-98----7229241615--124296
S67DTRKKDASDDLDDLN10122196-9976333090-10862847610194319102427018
S105VKDLKIESDVQEPTE10117561-8268656071-10258103951019328484374518
T111ESDVQEPTEPEDDLD101248113-10380362771-1086210899106974212101422318
S158NKKDDGISFSNQTGP499--------13755----2411304
S160KDDGISFSNQTGPAW17----------------52--
Showing 1 to 10 of 13 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S2______MSGDEMIFD2.5e-8----0.0652.5e-11-0.51--9.9e-4
T33DEEGDTQTEETQPSE5.3e-9-8.1e-5---1.6e-5----
T36GDTQTEETQPSETKE-----------
S39QTEETQPSETKEVEP0.37-----9.2e-8---4.6e-5-
T61LEADEEDTRKKDASD2.1e-10-----2.1e-10----
S67DTRKKDASDDLDDLN-8.9e-4-2.3e-80.082--9.8e-4-8.6e-3-7.5e-9--0.028-0.026
S105VKDLKIESDVQEPTE-4.8e-13-2.1e-10-0.71--1.6e-5-8.9e-6-3.3e-16--1.2e-9-0.036
T111ESDVQEPTEPEDDLD-3.2e-18-4.9e-9-0.2--8.7e-7-1.4e-11-3.2e-19-0.044-1e-130.35
S158NKKDDGISFSNQTGP-4.5e-4---------4.5e-4-
S160KDDGISFSNQTGPAW-----------
Showing 1 to 10 of 13 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationCCRCCS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationCOADS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationGBMS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationHNSCCS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationLSCCS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationLUADS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationOVS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationPDACS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylationUCECS2T33T36S39T61S67S105T111S158S160S218S286S310proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.