MAP3K20: mitogen-activated protein kinase kinase kinase 20
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5hes chain A
5hes chain B
5x5o chain A
6jut chain A
6juu chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S155 KICDFGAS RFHNHTT 1 9 - - - - 5 4 - - - - - - - - - - - - - - S264 ISILESMS NDTSLPD 1 6 - - 3 3 - - - - - - - - - - - - - - - - T267 LESMSNDT SLPDKCN 4 50 - - - - 10 16 - - 4 4 5 5 - - - - 5 1 - - S268 ESMSNDTS LPDKCNS 9 482 17 - 5 4 52 56 26 - 63 38 25 24 48 45 - - 12 5 55 7 S275 SLPDKCNS FLHNKAE 10 1156 52 - 99 76 44 46 46 - 103 58 108 99 101 92 14 4 81 32 83 18 T290 WRCEIEAT LERLKKL 1 9 - - - - - - - - - - - - - - 7 2 - - - - S302 KKLERDLS FKEQELK 4 110 9 - - - 24 30 - - - - 20 18 - - 7 2 - - - - T555 LAIQTLFT NSDGNPG 1 9 - - - - - - - - - - - - 5 4 - - - - - - S557 IQTLFTNS DGNPGSR 2 26 7 - - - - - - - - - 10 9 - - - - - - - - S563 NSDGNPGS RSDSSAD 2 36 - - - - - - - - - - 5 5 14 12 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S155 KICDFGAS RFHNHTT - - - - - - - - - - - S264 ISILESMS NDTSLPD - - - - - - - - - - - T267 LESMSNDT SLPDKCN - - - - - - - - - - - S268 ESMSNDTS LPDKCNS -3.7e-37 - - -1.8e-11 - -3.5e-5 -1.4e-7 -9e-21 - - - S275 SLPDKCNS FLHNKAE -3.3e-20 - 0.007 -1.4e-4 - -0.99 -3e-31 -1.1e-29 - 0.013 -5.1e-3 T290 WRCEIEAT LERLKKL - - - - - - - - - - - S302 KKLERDLS FKEQELK -6.3e-9 - - -4.3e-5 - - -3.8e-5 - - - - T555 LAIQTLFT NSDGNPG - - - - - - - - - - - S557 IQTLFTNS DGNPGSR - - - - - - - - - - - S563 NSDGNPGS RSDSSAD - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S155
S264
T267
S268
S275
T290
S302
T555
S557
S563
S567
S568
S584
T586
S587
S593
S599
T628
S633
S636
S637
S648
S649
T666
S667
S668
S685
S687
S690
S691
T704
S727
S733
S757
S781
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation CCRCC S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation COAD S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation GBM S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation HNSCC S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation LSCC S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation LUAD S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation OV S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation PDAC S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation UCEC S155 S264 T267 S268 S275 T290 S302 T555 S557 S563 S567 S568 S584 T586 S587 S593 S599 T628 S633 S636 S637 S648 S649 T666 S667 S668 S685 S687 S690 S691 T704 S727 S733 S757 S781 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S155
S264
T267
S268
S275
T290
S302
T555
S557
S563
S567
S568
S584
T586
S587
S593
S599
T628
S633
S636
S637
S648
S649
T666
S667
S668
S685
S687
S690
S691
T704
S727
S733
S757
S781
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S155
S264
T267
S268
S275
T290
S302
T555
S557
S563
S567
S568
S584
T586
S587
S593
S599
T628
S633
S636
S637
S648
S649
T666
S667
S668
S685
S687
S690
S691
T704
S727
S733
S757
S781
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.