Protein: ENSP00000364449
Gene: SIK3

LinkedOmicsKB © 2022-2023 Zhang Lab

SIK3:
SIK family kinase 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S34LPPPAPGSPAAPAAV72139-1616--53-542421--62--534
T221TPGQLLKTWCGSPPY10118496-5549362790-915210395110101295101438318
S225LLKTWCGSPPYAAPE395------81-------71--6-
Y228TWCGSPPYAAPELFE18--------53----------
T469YLSMRRHTVGVADPR10122198-80619710099-78477467575276179741746
S551GPLGRRASDGGANIQ101467122-10380949499-108621089910697388105438318
T578PSPLVTMTPAVPAVT19------9-------------
T585TPAVPAVTPVDEESS247------26-----------912
S591VTPVDEESSDGEPDQ19------9-------------
S592TPVDEESSDGEPDQE5185--2020--72---242344----18-
Showing 1 to 10 of 39 rows
102550
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S34LPPPAPGSPAAPAAV0.021-----0.021----
T221TPGQLLKTWCGSPPY-5.6e-43--1.5e-4-4.5e-5--1.5e-12-2.1e-18-1.6e-20-0.17-2.0e-6
S225LLKTWCGSPPYAAPE-----------
Y228TWCGSPPYAAPELFE-----------
T469YLSMRRHTVGVADPR-9.4e-29-0.14-1.9e-26--5.2e-3-8.7e-11-1.4e-4-0.72-8.8e-12-
S551GPLGRRASDGGANIQ-1.2e-3-2.7e-20-2.4e-14-0.72-4.6e-5-6.4e-14-2.2e-7-0.002
T578PSPLVTMTPAVPAVT-----------
T585TPAVPAVTPVDEESS-----------
S591VTPVDEESSDGEPDQ-----------
S592TPVDEESSDGEPDQE-6.7e-4--0.012----0.021----
Showing 1 to 10 of 39 rows
102550
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationCCRCCS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationCOADS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationGBMS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationHNSCCS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationLSCCS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationLUADS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationOVS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationPDACS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylationUCECS34T221S225Y228T469S551T578T585S591S592T616S620S626S631S647S730S731S746S748S834S836S838S866S869S902S915S974S978T1057S1058T1078Y1083S1092S1094S1124S1182S1202T1217S1221proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.