ARHGEF7: Rho guanine nucleotide exchange factor 7
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1by1 chain A
1zsg chain A
2l3g chain A
5sxp chain A
5sxp chain B
5sxp chain C
5sxp chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S25 ESPKKTIS DPEGFLQ 7 991 - - 78 72 - - 45 - 97 55 108 99 110 101 - - 89 37 82 18 S123 QNFNKVLS SLVTLNK 3 74 - - 5 4 - - - - - - 25 24 9 7 - - - - - - S124 NFNKVLSS LVTLNKV 1 16 - - 8 8 - - - - - - - - - - - - - - - - S139 TADIGLGS DSVCARP 1 8 - - 4 4 - - - - - - - - - - - - - - - - S141 DIGLGSDS VCARPSS 2 34 - - 13 12 - - - - - - - - - - - - 7 2 - - S148 SVCARPSS HRIKSFD 2 60 - - - - - - 36 - - - - - - - - - - - 17 7 S153 PSSHRIKS FDSLGSQ 4 263 - - - - - - 99 - 63 34 20 19 - - - - - - 17 11 S176 LFQGQYRS LDMTDNS 7 191 - - 9 8 - - 55 - 12 8 10 9 5 4 - - 7 3 52 9 T198 AKFNFQQT NEDELSF 1 9 - - - - - - 9 - - - - - - - - - - - - - S249 KASEKPVS PKSGTLK 7 1098 - - 90 68 - - 99 - 108 62 108 99 110 101 - - 105 44 95 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S25 ESPKKTIS DPEGFLQ -1.2e-65 - -3.2e-9 - - -1.2e-20 -3.5e-29 -1.4e-30 - 0.01 -6.3e-11 S123 QNFNKVLS SLVTLNK -2.1e-12 - - - - - -2.1e-12 - - - - S124 NFNKVLSS LVTLNKV - - - - - - - - - - - S139 TADIGLGS DSVCARP - - - - - - - - - - - S141 DIGLGSDS VCARPSS - - - - - - - - - - - S148 SVCARPSS HRIKSFD - - - - - - - - - - - S153 PSSHRIKS FDSLGSQ -8e-8 - - - - -5.5e-7 -9.9e-3 - - - - S176 LFQGQYRS LDMTDNS - - - - - - - - - - - T198 AKFNFQQT NEDELSF - - - - - - - - - - - S249 KASEKPVS PKSGTLK 1.9e-4 - 8.4e-14 - - 4.8e-6 0.021 -0.075 - -2.5e-5 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S25
S123
S124
S139
S141
S148
S153
S176
T198
S249
S257
S295
S392
S393
S518
T528
T534
S551
S581
T586
T596
T603
S651
S676
S694
S768
S771
S774
Y776
S794
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation CCRCC S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation COAD S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation GBM S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation HNSCC S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation LSCC S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation LUAD S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation OV S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation PDAC S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation UCEC S25 S123 S124 S139 S141 S148 S153 S176 T198 S249 S257 S295 S392 S393 S518 T528 T534 S551 S581 T586 T596 T603 S651 S676 S694 S768 S771 S774 Y776 S794 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S25
S123
S124
S139
S141
S148
S153
S176
T198
S249
S257
S295
S392
S393
S518
T528
T534
S551
S581
T586
T596
T603
S651
S676
S694
S768
S771
S774
Y776
S794
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S25
S123
S124
S139
S141
S148
S153
S176
T198
S249
S257
S295
S392
S393
S518
T528
T534
S551
S581
T586
T596
T603
S651
S676
S694
S768
S771
S774
Y776
S794
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.