SYK: spleen associated tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1a81 chain A
1a81 chain C
1a81 chain E
1a81 chain G
1a81 chain I
1a81 chain K
1csy chain A
1csz chain A
1xba chain A
1xbb chain A
1xbc chain A
3buw chain A
3buw chain C
3emg chain A
3fqe chain A
3fqh chain A
3fqh chain B
3fqs chain A
3srv chain A
3srv chain B
3tub chain A
3tuc chain A
3tud chain A
3vf8 chain A
3vf9 chain A
4dfl chain A
4dfn chain A
4f4p chain A
4fl1 chain A
4fl2 chain A
4fl3 chain A
4fyn chain A
4fyo chain A
4fz6 chain A
4fz7 chain A
4gfg chain A
4i0r chain A
4i0s chain A
4i0t chain A
4puz chain A
4puz chain B
4pv0 chain A
4px6 chain A
4rss chain A
4rx7 chain A
4rx8 chain A
4rx9 chain A
4wnm chain A
4xg2 chain A
4xg3 chain A
4xg3 chain B
4xg4 chain A
4xg6 chain A
4xg7 chain A
4xg8 chain A
4xg8 chain C
4xg9 chain A
4xg9 chain B
4yjo chain A
4yjp chain A
4yjq chain A
4yjr chain A
4yjs chain A
4yjt chain A
4yju chain A
4yjv chain A
5c26 chain A
5c27 chain A
5cxh chain A
5cxz chain A
5cy3 chain A
5ghv chain A
5ghv chain B
5lma chain A
5lmb chain A
5lmb chain B
5t68 chain A
5t68 chain B
5tiu chain A
5tr6 chain A
5tt7 chain A
5y5t chain A
5y5u chain A
5y5u chain B
6hm6 chain A
6hm7 chain A
6ssb chain A
6vov chain A
6vov chain B
6zc0 chain A
6zcp chain A
6zcq chain A
6zcr chain A
6zcs chain A
6zcu chain A
6zcx chain A
6zcy chain A
7q5t chain AAA
7q5t chain BBB
7q5t chain CCC
7q5t chain DDD
7q5t chain EEE
7q5t chain FFF
7q5u chain AAA
7q5u chain BBB
7q5u chain CCC
7q5u chain DDD
7q5u chain EEE
7q5u chain FFF
7q5w chain AAA
7q5w chain BBB
7q5w chain CCC
7q5w chain DDD
7q5w chain EEE
7q5w chain FFF
7q63 chain AAA
7q63 chain BBB
7q63 chain CCC
7sa7 chain A
7sa7 chain B
7sa7 chain C
7sa7 chain D
7sa7 chain E
7sa7 chain F
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S35 YLVQGGMS DGLYLLR 1 9 - - - - - - - - - - 5 4 - - - - - - - - Y74 ERELNGTY AIAGGRT 1 18 - - - - - - - - - - - - - - - - - - 15 3 S178 GKISREES EQIVLIG 3 26 - - 4 4 - - - - - - - - 5 4 - - - - 7 2 Y203 ARDNNGSY ALCLLHE 1 17 - - - - - - - - - - - - 9 8 - - - - - - S295 GIISRIKS YSFPKPG 4 88 8 - - - 33 30 - - - - - - 5 4 7 1 - - - - S297 ISRIKSYS FPKPGHR 6 458 82 - - - 55 53 - - - - 58 52 49 44 42 9 10 4 - - S307 KPGHRKSS PAQGNRQ 3 78 66 - - - - - - - - - - - - - 6 2 2 2 - - S316 AQGNRQES TVSFNPY 2 17 - - - - - - - - - - - - - - 7 1 - - 7 2 T317 QGNRQEST VSFNPYE 3 85 - - - - - - 10 - - - 25 24 14 12 - - - - - - S319 NRQESTVS FNPYEPE 4 64 - - - - - - - - 7 3 10 9 14 12 - - - - 7 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S35 YLVQGGMS DGLYLLR - - - - - - - - - - - Y74 ERELNGTY AIAGGRT - - - - - - - - - - - S178 GKISREES EQIVLIG - - - - - - - - - - - Y203 ARDNNGSY ALCLLHE - - - - - - - - - - - S295 GIISRIKS YSFPKPG 0.52 - - 0.52 - - - - - - - S297 ISRIKSYS FPKPGHR 0.038 - - 1.8e-3 - - -0.014 3.5e-3 - - - S307 KPGHRKSS PAQGNRQ - - - - - - - - - - - S316 AQGNRQES TVSFNPY - - - - - - - - - - - T317 QGNRQEST VSFNPYE 0.026 - - - - - 0.026 - - - - S319 NRQESTVS FNPYEPE - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S35
Y74
S178
Y203
S295
S297
S307
S316
T317
S319
Y323
S350
Y352
T371
S379
Y525
Y526
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation CCRCC S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation COAD S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation GBM S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation HNSCC S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation LSCC S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation LUAD S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation OV S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation PDAC S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation UCEC S35 Y74 S178 Y203 S295 S297 S307 S316 T317 S319 Y323 S350 Y352 T371 S379 Y525 Y526 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S35
Y74
S178
Y203
S295
S297
S307
S316
T317
S319
Y323
S350
Y352
T371
S379
Y525
Y526
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S35
Y74
S178
Y203
S295
S297
S307
S316
T317
S319
Y323
S350
Y352
T371
S379
Y525
Y526
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.