HCK: HCK proto-oncogene, Src family tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ad5 chain A
1ad5 chain B
1bu1 chain A
1bu1 chain B
1bu1 chain C
1bu1 chain D
1bu1 chain E
1bu1 chain F
1qcf chain A
2c0i chain A
2c0i chain B
2c0o chain A
2c0o chain B
2c0t chain A
2c0t chain B
2hck chain A
2hck chain B
2hk5 chain A
2oi3 chain A
2oj2 chain A
3hck chain A
3nhn chain A
3rbb chain B
3rbb chain D
3rea chain B
3rea chain D
3reb chain B
3reb chain D
3vry chain A
3vry chain B
3vrz chain A
3vrz chain B
3vs0 chain A
3vs0 chain B
3vs1 chain A
3vs1 chain B
3vs2 chain A
3vs2 chain B
3vs3 chain A
3vs3 chain B
3vs4 chain A
3vs4 chain B
3vs5 chain A
3vs5 chain B
3vs6 chain A
3vs6 chain B
3vs7 chain A
3vs7 chain B
4hck chain A
4lud chain A
4lud chain B
4lue chain A
4lue chain B
4orz chain A
4u5w chain B
4u5w chain D
5h09 chain A
5h0b chain A
5h0e chain A
5h0g chain A
5h0h chain A
5hck chain A
5nuh chain C
5nuh chain D
5zj6 chain A
5zj6 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T36 FLQVGGNT FSKTETS 10 1118 73 - 90 68 40 32 81 - 108 62 98 90 92 85 76 18 46 18 35 6 S38 QVGGNTFS KTETSAS 8 277 9 - 4 4 - - 62 - 7 2 28 26 45 40 5 3 - - 35 7 S45 SKTETSAS PHCPVYV 4 91 - - 4 4 - - - - 23 13 20 18 5 4 - - - - - - S68 PGPNSHNS NTPGIRE 4 111 - - - - - - 27 - - - 15 15 14 12 - - - - 24 4 S111 QMVVLEES GEWWKAR 5 410 46 - 8 - - - 18 - - - 79 71 98 90 - - - - - - T202 VKHYKIRT LDNGGFY 8 218 - - 5 4 10 8 36 - 7 3 25 24 17 16 35 8 13 7 - - Y209 TLDNGGFY ISPRSTF 5 170 - - - - - - - - 19 9 35 32 23 20 15 3 10 4 - - S211 DNGGFYIS PRSTFST 5 73 - - 12 2 - - - - - - 5 5 9 7 22 4 5 2 - - Y226 LQELVDHY KKGNDGL 1 10 - - - - - - - - - - 5 5 - - - - - - - - S261 AWEIPRES LKLEKKL 2 97 - - - - - - - - - - 20 20 30 27 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T36 FLQVGGNT FSKTETS 6e-40 - 5e-21 0.034 - 1.2e-18 4.6e-8 1.1e-9 0.67 7.6e-3 - S38 QVGGNTFS KTETSAS 4.4e-5 - - - - - 1.5e-3 9.3e-3 - - - S45 SKTETSAS PHCPVYV 0.22 - - - - 0.11 0.87 - - - - S68 PGPNSHNS NTPGIRE - - - - - - - - - - - S111 QMVVLEES GEWWKAR -1.8e-15 - - - - - -1.7e-11 -6.4e-6 - - - T202 VKHYKIRT LDNGGFY -0.21 - - - - - -0.21 - - - - Y209 TLDNGGFY ISPRSTF -5.7e-6 - - - - - -4.9e-3 -3.1e-4 - - - S211 DNGGFYIS PRSTFST - - - - - - - - - - - Y226 LQELVDHY KKGNDGL - - - - - - - - - - - S261 AWEIPRES LKLEKKL 1.5e-10 - - - - - 4.5e-5 6.3e-7 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T36
S38
S45
S68
S111
T202
Y209
S211
Y226
S261
Y330
S520
Y522
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation CCRCC T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation COAD T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation GBM T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation HNSCC T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation LSCC T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation LUAD T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation OV T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation PDAC T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation UCEC T36 S38 S45 S68 S111 T202 Y209 S211 Y226 S261 Y330 S520 Y522 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T36
S38
S45
S68
S111
T202
Y209
S211
Y226
S261
Y330
S520
Y522
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T36
S38
S45
S68
S111
T202
Y209
S211
Y226
S261
Y330
S520
Y522
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.