Protein: ENSP00000365588

MDC1:: mediator of DNA damage checkpoint 1

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S108	LRPPKVLSPGVSHRL	10	1101	89	-	68	56	36	36	90	-	64	33	88	82	101	92	83	19	61	26	61	16
T157	TPRVQGETQPQRLLL	1	26	-	-	-	-	-	-	-	-	-	-	-	-	-	-	23	3	-	-	-	-
S168	RLLLAEDSEEEVDFL	10	1465	111	-	103	80	94	94	96	-	108	62	94	85	106	97	71	14	97	40	95	18
S176	EEEVDFLSERRMVKK	2	19	9	-	-	-	-	-	-	-	-	-	5	5	-	-	-	-	-	-	-	-
S292	AGVILERSQPPGEDS	6	441	56	-	-	-	14	13	80	-	-	-	58	54	70	64	-	-	-	-	29	3
S299	SQPPGEDSDTDVDDD	10	1199	95	-	99	76	67	67	72	-	77	42	108	97	89	80	18	4	89	36	68	15
T301	PPGEDSDTDVDDDSR	10	322	113	-	16	6	9	9	14	-	12	5	10	9	5	4	4	3	2	1	82	18
S307	DTDVDDDSRPPGRPA	3	168	53	-	4	4	-	-	-	-	-	-	58	49	-	-	-	-	-	-	-	-
S329	QPFGFIDSDTDAEEE	10	1189	113	-	37	36	90	81	89	-	90	52	89	80	97	88	64	14	39	17	95	18
T331	FGFIDSDTDAEEERI	9	404	47	-	18	16	62	72	9	-	11	8	14	12	21	20	-	-	9	2	67	16

Showing 1 to 10 of 121 rows

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Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S108	LRPPKVLSPGVSHRL	5.5e-17	-	-3.0e-6	3.5e-4	-	3.1e-9	4.5e-12	1.5e-6	7.2e-5	0.087	0.15
T157	TPRVQGETQPQRLLL	-	-	-	-	-	-	-	-	-	-	-
S168	RLLLAEDSEEEVDFL	0.65	-	-0.53	-6.9e-5	-	0.77	2.3e-8	0.6	-0.42	-0.88	0.67
S176	EEEVDFLSERRMVKK	-	-	-	-	-	-	-	-	-	-	-
S292	AGVILERSQPPGEDS	6e-12	-	-	-	-	-	6.1e-5	1.1e-8	-	-	-
S299	SQPPGEDSDTDVDDD	7.5e-9	-	-2.1e-5	1.4e-8	-	0.6	3.2e-17	1.7e-11	-	-3.9e-5	0.023
T301	PPGEDSDTDVDDDSR	0.44	-	-	-	-	-	-	-	-	-	0.44
S307	DTDVDDDSRPPGRPA	6.5e-8	-	-	-	-	-	6.5e-8	-	-	-	-
S329	QPFGFIDSDTDAEEE	1.3e-4	-	-0.025	0.58	-	0.95	1.5e-17	2.9e-5	0.056	0.75	-0.013
T331	FGFIDSDTDAEEERI	-0.27	-	-	-1.2e-3	-	-	-	4.2e-5	-	-	-5.7e-3

Showing 1 to 10 of 121 rows

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* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000365588Gene: MDC1

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000365588
Gene: MDC1