PPP1CA: protein phosphatase 1 catalytic subunit alpha
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3e7a chain A
3e7a chain B
3e7b chain A
3e7b chain B
3egg chain A
3egg chain B
3egh chain A
3egh chain B
3hvq chain A
3hvq chain B
3n5u chain A
3n5u chain B
3v4y chain A
3v4y chain C
3v4y chain E
3v4y chain G
4g9j chain A
4g9j chain B
4mov chain A
4mov chain B
4moy chain A
4mp0 chain A
4mp0 chain C
4xpn chain A
4xpn chain C
5ioh chain A
5ioh chain C
6alz chain A
6alz chain B
6czo chain A
6czo chain C
6dcx chain A
6dcx chain B
6dno chain A
6g0i chain A
6g0j chain A
6ghm chain A
6ghm chain B
6obn chain A
6obn chain B
6obp chain A
6obq chain A
6obq chain B
6obr chain A
6obr chain B
6obs chain A
6obs chain B
6obu chain A
6obu chain B
6zee chain A
6zee chain B
6zee chain I
6zee chain K
6zee chain P
6zee chain Q
6zef chain A
6zef chain B
6zeg chain A
6zeg chain B
6zeh chain A
6zeh chain B
6zei chain A
6zei chain B
6zej chain A
6zej chain D
6zej chain F
6zej chain I
6zej chain L
6zej chain O
6zk6 chain A
7tvf chain C
7tvf chain F
7txh chain C
7txh chain F
7upi chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S22 RLLEVQGS RPGKNVQ 6 261 34 - 44 35 - - 19 - - - 15 15 34 33 - - 24 8 - - Y306 ADKNKGKY GQFSGLN 1 20 - - - - - - - - - - 10 10 - - - - - - - - S310 KGKYGQFS GLNPGGR 1 14 - - - - - - - - - - - - - - - - - - 12 2 T320 NPGGRPIT PPRNSAK 9 1412 - - 103 80 94 94 99 - 108 62 108 99 110 101 75 17 105 44 95 18 S325 PITPPRNS AKAKK__ 8 883 - - 36 34 - - 72 - 103 59 78 71 93 86 33 9 100 42 49 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S22 RLLEVQGS RPGKNVQ -0.27 - 0.71 - - - - -0.052 - - - Y306 ADKNKGKY GQFSGLN - - - - - - - - - - - S310 KGKYGQFS GLNPGGR - - - - - - - - - - - T320 NPGGRPIT PPRNSAK 3.9e-28 - 5.5e-24 1.2e-8 - 0.014 -0.088 2.7e-5 7.5e-3 1.5e-6 4.1e-3 S325 PITPPRNS AKAKK__ 9.3e-7 - -0.34 - - 6.6e-7 0.56 2.8e-10 - 0.27 0.99
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S22
Y306
S310
T320
S325
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S22 Y306 S310 T320 S325 protein RNA SCNV methylation CCRCC S22 Y306 S310 T320 S325 protein RNA SCNV methylation COAD S22 Y306 S310 T320 S325 protein RNA SCNV methylation GBM S22 Y306 S310 T320 S325 protein RNA SCNV methylation HNSCC S22 Y306 S310 T320 S325 protein RNA SCNV methylation LSCC S22 Y306 S310 T320 S325 protein RNA SCNV methylation LUAD S22 Y306 S310 T320 S325 protein RNA SCNV methylation OV S22 Y306 S310 T320 S325 protein RNA SCNV methylation PDAC S22 Y306 S310 T320 S325 protein RNA SCNV methylation UCEC S22 Y306 S310 T320 S325 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S22
Y306
S310
T320
S325
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S22
Y306
S310
T320
S325
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.