Protein: ENSP00000366244
Gene: ARAF

LinkedOmicsKB © 2022-2023 Zhang Lab

ARAF:
A-Raf proto-oncogene, serine/threonine kinase

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S157NRQQFYHSVQDLSGG71033--10380--80-9757108998376--96419518
S162YHSVQDLSGGSRQHE7897--9168--89-684289808781--96414718
T181RPLNELLTPQGPSPR7917--6653--87-975583769383--96426818
S186LLTPQGPSPRTQHCD71017--8160--98-82471039510696--100428918
S212APLQRIRSTSTPNVH358------9---------44347
T213PLQRIRSTSTPNVHM333--44------------124-9
S214LQRIRSTSTPNVHMV7533--88--88-543552494744--42197116
T215QRIRSTSTPNVHMVS7900--9472--64-1035868639688--76336916
T224NVHMVSTTAPMDSNL18--44----------------
S229STTAPMDSNLIQLTG19------9-------------
Showing 1 to 10 of 26 rows
102550
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S157NRQQFYHSVQDLSGG1e-7-6.5e-5--1.6e-32.1e-47.8e-5-0.33-5.7e-3
S162YHSVQDLSGGSRQHE-0.065-2.9e-6--0.73-2.9e-80.41--0.22-3.2e-4
T181RPLNELLTPQGPSPR-0.39-2.5e-12---0.051-0.0270.23--1.2e-110.51
S186LLTPQGPSPRTQHCD0.5-3e-11--4.5e-5-4.9e-60.61--3e-90.35
S212APLQRIRSTSTPNVH-----------
T213PLQRIRSTSTPNVHM-----------
S214LQRIRSTSTPNVHMV-0.015-----8.4e-4-0.0390.98--0.30.34
T215QRIRSTSTPNVHMVS-4e-11-2.2e-3---2.7e-11-1.2e-6-2.7e-6--0.15-0.11
T224NVHMVSTTAPMDSNL-----------
S229STTAPMDSNLIQLTG-----------
Showing 1 to 10 of 26 rows
102550
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationCCRCCS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationCOADS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationGBMS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationHNSCCS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationLSCCS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationLUADS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationOVS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationPDACS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylationUCECS157S162T181S186S212T213S214T215T224S229T253S257S259S265S269S272S274S283Y301Y302T318S320T455S458S547S600proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.