IRF3: interferon regulatory factor 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1j2f chain A
1j2f chain B
1qwt chain A
1qwt chain B
1t2k chain A
1t2k chain B
1zoq chain A
1zoq chain B
2o61 chain A
2o6g chain E
2o6g chain F
2o6g chain G
2o6g chain H
2pi0 chain A
2pi0 chain B
2pi0 chain C
2pi0 chain D
3a77 chain A
3a77 chain B
3a77 chain C
3a77 chain D
3qu6 chain A
3qu6 chain B
3qu6 chain C
5jej chain A
5jej chain B
5jek chain A
5jek chain B
5jel chain A
5jem chain A
5jem chain B
5jem chain E
5jem chain G
5jeo chain A
5jer chain A
5jer chain C
5jer chain E
5jer chain G
6siv chain A
6sja chain A
7jfl chain A
7jfl chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S159 LPDPGPPS LAVAPEP 3 24 - - 4 4 - - - - 6 3 - - - - - - 5 2 - - S173 PCPQPLRS PSLDNPT 4 138 - - - - - - - - - - 40 37 - - 32 10 3 2 11 3 S175 PQPLRSPS LDNPTPF 10 1486 106 - 89 68 97 100 99 - 108 62 103 94 110 101 76 16 105 44 90 18 T180 SPSLDNPT PFPNLGP 2 16 8 - - - - - - - - - - - 4 4 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S159 LPDPGPPS LAVAPEP - - - - - - - - - - - S173 PCPQPLRS PSLDNPT -0.73 - - - - - 0.91 - -0.55 - - S175 PQPLRSPS LDNPTPF 2.9e-4 - 4.1e-26 -0.25 - 8e-7 -1.8e-4 0.45 -0.19 2.1e-4 -0.24 T180 SPSLDNPT PFPNLGP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S159
S173
S175
T180
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S159 S173 S175 T180 protein RNA SCNV methylation CCRCC S159 S173 S175 T180 protein RNA SCNV methylation COAD S159 S173 S175 T180 protein RNA SCNV methylation GBM S159 S173 S175 T180 protein RNA SCNV methylation HNSCC S159 S173 S175 T180 protein RNA SCNV methylation LSCC S159 S173 S175 T180 protein RNA SCNV methylation LUAD S159 S173 S175 T180 protein RNA SCNV methylation OV S159 S173 S175 T180 protein RNA SCNV methylation PDAC S159 S173 S175 T180 protein RNA SCNV methylation UCEC S159 S173 S175 T180 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S159
S173
S175
T180
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S159
S173
S175
T180
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.