Protein: ENSP00000368884
Gene: RPS6KA3

LinkedOmicsKB © 2022-2023 Zhang Lab

RPS6KA3:
ribosomal protein S6 kinase A3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S17WQKMAVESPSDSAEN5116----1089---1515----74426
S19KMAVESPSDSAENGQ888548-99762331--7947837610292--6224367
S21AVESPSDSAENGQQI61017-88----107552320--62--
T348HPPFKPATGRPEDTF235--124----136----------
T354ATGRPEDTFYFDPEF233--88--------98------
T365DPEFTAKTPKDSPGI10139182-10380918899-10862108991101017297419518
S369TAKTPKDSPGIPPSA101527113-103809710099-1086210899110101831994389518
S375DSPGIPPSANAHQLF1068314-9572505799-613910109938726125718
S386HQLFRGFSFVAITSD9116178-8772778499-1086210899110101--431716-
T391GFSFVAITSDDESQA436--44--9---5554------
Showing 1 to 10 of 18 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S17WQKMAVESPSDSAEN-----------
S19KMAVESPSDSAENGQ-7.7e-3-7.6e-30.3--6.9e-11-1.2e-11-0.83-0.001-
S21AVESPSDSAENGQQI2.5e-5------2.5e-5---
T348HPPFKPATGRPEDTF-----------
T354ATGRPEDTFYFDPEF-----------
T365DPEFTAKTPKDSPGI-6.2e-10-0.0710.91--2.3e-10-1.2e-29-1.9e-5-2.4e-6-0.28
S369TAKTPKDSPGIPPSA-2.7e-6-0.22-0.003-0.032-9.0e-5-1.5e-21-5.0e-40.210.043
S375DSPGIPPSANAHQLF-9.9e-4-0.03-0.09--5.4e-11---0.27-0.017
S386HQLFRGFSFVAITSD-8e-20-0.64-5.3e-11--1.5e-19-2.3e-5-0.014--0.61-
T391GFSFVAITSDDESQA-----------
Showing 1 to 10 of 18 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationCCRCCS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationCOADS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationGBMS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationHNSCCS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationLSCCS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationLUADS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationOVS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationPDACS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylationUCECS17S19S21T348T354T365S369S375S386T391S392S396S415T419Y422S641Y644S715proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.