DDX58: DExD/H-box helicase 58
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2lwd chain A
2lwe chain A
2qfb chain A
2qfb chain B
2qfb chain C
2qfb chain D
2qfb chain E
2qfb chain F
2qfb chain G
2qfb chain H
2qfb chain I
2qfb chain J
2qfd chain A
2qfd chain B
2qfd chain C
2qfd chain D
2qfd chain E
2qfd chain F
2qfd chain G
2qfd chain H
2qfd chain I
2qfd chain J
2rmj chain A
2ykg chain A
3lrn chain A
3lrn chain B
3lrr chain A
3lrr chain B
3ncu chain A
3ncu chain B
3og8 chain A
3og8 chain B
3zd6 chain A
3zd7 chain A
4ay2 chain A
4bpb chain A
4nqk chain A
4nqk chain B
4nqk chain C
4nqk chain D
4on9 chain A
4on9 chain B
4p4h chain A
4p4h chain B
4p4h chain C
4p4h chain D
4p4h chain E
4p4h chain F
4p4h chain G
4p4h chain H
5e3h chain A
5f98 chain A
5f98 chain C
5f98 chain E
5f98 chain G
5f98 chain I
5f98 chain K
5f9f chain A
5f9f chain C
5f9f chain E
5f9f chain G
5f9f chain I
5f9f chain K
5f9h chain A
5f9h chain C
5f9h chain E
5f9h chain G
5f9h chain I
5f9h chain K
6gpg chain A
6kyv chain B
6kyv chain D
6kyv chain F
6kyv chain H
6kyv chain J
6kyv chain L
7bah chain A
7bah chain B
7bai chain A
7bai chain B
7bai chain E
7jl1 chain A
7jl3 chain A
7jl3 chain C
7jl3 chain E
7mk1 chain A
7mk1 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S8 MTTEQRRS LQAFQDY 6 256 32 - - - - - - - 29 17 20 19 - - 35 6 20 7 64 7 S239 VSDTNLYS PFKPRNY 1 6 - - - - - - - - - - - - - - - - 5 1 - - S743 SKCFLLTS NAGVIEK 1 7 - - - - - - - - - - - - - - - - - - 7 - T770 DSILRLQT WDEAVFR 4 68 - - 4 4 - - - - 7 3 10 8 - - - - - - 30 2 S855 PKPKQFSS FEKRAKI 7 296 - - 9 8 - - 36 - 19 10 5 4 23 21 - - 65 27 51 18 S870 FCARQNCS HDWGIHV 1 11 - - - - - - - - - - - - - - - - 9 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S8 MTTEQRRS LQAFQDY -0.014 - - - - 0.4 -1.6e-5 - - - - S239 VSDTNLYS PFKPRNY - - - - - - - - - - - S743 SKCFLLTS NAGVIEK - - - - - - - - - - - T770 DSILRLQT WDEAVFR - - - - - - - - - - - S855 PKPKQFSS FEKRAKI 1e-9 - - - - - - 1.6e-4 - 6.4e-5 0.005 S870 FCARQNCS HDWGIHV - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S8
S239
S743
T770
S855
S870
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation CCRCC S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation COAD S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation GBM S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation HNSCC S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation LSCC S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation LUAD S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation OV S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation PDAC S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation UCEC S8 S239 S743 T770 S855 S870 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S8
S239
S743
T770
S855
S870
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S8
S239
S743
T770
S855
S870
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.