Protein: ENSP00000369677
Gene: EMILIN1

LinkedOmicsKB © 2022-2023 Zhang Lab

EMILIN1:
elastin microfibril interfacer 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S156RPARPNLSGSSAGSP16----------------51--
S158ARPNLSGSSAGSPLS16----------------51--
S159RPNLSGSSAGSPLSG113----------------94--
S269NNHHGGSSSSGGSRA18------8-------------
T385VLSGRRGTELGGAAG36622-------63----296----
S421FNSTLGPSEEQEESW19--------63----------
T701QEATEHATESEERFR2159---------------42--
S703ATEHATESEERFRGL85606---7875--442345394477169439511
S722AQAGQCPSLEGRLGR118----612--------------
S839GPAGPPGSPGKDGQE18--------------53----
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S156RPARPNLSGSSAGSP-----------
S158ARPNLSGSSAGSPLS-----------
S159RPNLSGSSAGSPLSG-----------
S269NNHHGGSSSSGGSRA-----------
T385VLSGRRGTELGGAAG-----------
S421FNSTLGPSEEQEESW-----------
T701QEATEHATESEERFR-----------
S703ATEHATESEERFRGL1.4e-7--2.6e-3-1.2e-41.1e-7--0.140.3-
S722AQAGQCPSLEGRLGR-----------
S839GPAGPPGSPGKDGQE-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: StromalScoreS7035.7e-12--1.1e-3-0.0888.2e-5-7.6e-41.8e-3-
ESTIMATE: ESTIMATEScoreS7035.1e-11--9.0e-4-0.492.1e-5-0.0044.0e-4-
HALLMARK_KRAS_SIGNALING_UPS7038.3e-11--9.5e-3-0.32.8e-4-4.6e-39.4e-6-
KINASE-PSP_PKACA/PRKACAS7031.4e-10--3.5e-5-0.463.5e-3-1.4e-60.086-
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONS7035e-10--2.2e-3-0.0240.022-1.2e-32.2e-3-
xcell: stroma scoreS7033.6e-9--0.039-0.114.2e-3-7.5e-56.5e-3-
HALLMARK_IL2_STAT5_SIGNALINGS7034e-9--0.014-0.721.1e-3-4.4e-32.4e-5-
HALLMARK_COAGULATIONS7034.8e-9--0.018-0.111.2e-3-5.2e-30.002-
xcell: Cancer associated fibroblastS7031.3e-8--0.21-0.036.7e-3-5.3e-50.011-
xcell: Myeloid dendritic cell activatedS7035.1e-8--1.1e-3--0.871.6e-6-0.173.3e-3-
Showing 1 to 10 of 2580 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationCCRCCS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationCOADS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationGBMS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationHNSCCS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationLSCCS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationLUADS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationOVS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationPDACS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylationUCECS156S158S159S269T385S421T701S703S722S839proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PDGFRBS7038.4e-16--6.9e-4-2.4e-33.7e-3-2.4e-59.1e-6-
PDGFRAS7039.5e-10--0.52-0.0541.9e-3-1.4e-76.2e-3-
ILKS7032.4e-9--3.9e-3-0.10.001-2.3e-50.19-
DDR2S7031.6e-8--0.091-3.5e-30.18-2.9e-42.3e-3-
CSF1RS7033e-8--0.15-0.0779.0e-4-1.9e-40.033-
ROR2S7038.9e-8--0.03-0.0180.033-0.0883.6e-4-
AKT3S7032e-7--0.035-1.8e-40.84-2.3e-30.012-
PRKG1S7033.1e-7--0.07-0.0292.8e-3-2.7e-40.42-
MYLKS7034.8e-7--0.23-0.0783.6e-4-1.0e-50.75-
BTKS7039.3e-7--0.73-0.182.5e-4-5.2e-34.3e-3-
Showing 1 to 10 of 5380 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PPM1GS703-1.7e-7---4.4e-3--0.3-2.2e-4--0.1-0.013-
SSU72S703-9.7e-7---0.011--0.014-0.032--0.016-0.16-
PPP4CS703-1.7e-5---0.57--0.066-0.002--0.015-0.091-
ILKAPS703-6.4e-5---0.074--0.65-5.8e-3--0.071-0.033-
HDHD5S703-1.3e-4---4.5e-3-0.88-1.2e-3--0.022-0.76-
ACP1S703-3.6e-4---0.54--0.27-0.13--2.1e-3-0.1-
PTPRFS703-4.5e-4---0.37-0.83-8.4e-3--2.9e-3-0.12-
PTP4A1S703-1.2e-3---0.019--0.15-0.025--0.33-0.8-
NT5C3AS703-3.8e-3---0.029--0.0320.024--0.12-4.5e-3-
GAKS703-6.6e-3---0.11--0.310.12--0.17-3.2e-4-
Showing 1 to 10 of 2400 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.