RPS6: ribosomal protein S6
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4ug0 chain SG
4v6x chain AG
5a2q chain G
5aj0 chain BG
5flx chain G
5lks chain SG
5oa3 chain G
5t2c chain AK
5vyc chain G1
5vyc chain G2
5vyc chain G3
5vyc chain G4
5vyc chain G5
5vyc chain G6
6f4p chain B
6f4q chain B
6fec chain q
6g18 chain G
6g4s chain G
6g4w chain G
6g51 chain G
6g53 chain G
6g5h chain G
6g5i chain G
6ip5 chain 3H
6ip6 chain 3H
6ip8 chain 3H
6ole chain SG
6olf chain SG
6olg chain BG
6oli chain SG
6olz chain BG
6om0 chain SG
6om7 chain SG
6qzp chain SG
6xa1 chain SG
6y0g chain SG
6y2l chain SG
6y57 chain SG
6ybw chain S
6z6l chain SG
6z6m chain SG
6z6n chain SG
6zlw chain G
6zm7 chain SG
6zme chain SG
6zmi chain SG
6zmo chain SG
6zmt chain G
6zmw chain S
6zn5 chain G
6zoj chain G
6zok chain G
6zon chain r
6zp4 chain r
6zuo chain G
6zv6 chain G
6zvh chain G
6zvj chain r
6zxd chain G
6zxe chain G
6zxf chain G
6zxg chain G
6zxh chain G
7a09 chain r
7k5i chain G
7mq8 chain L6
7mq9 chain L6
7mqa chain L6
7qp6 chain S
7qp7 chain S
7tql chain G
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S82 LLLSKGHS CYRPRRT 2 137 - - - - - - 54 - - - 43 40 - - - - - - - - S235 IAKRRRLS SLRASTS 7 704 - - 4 4 - - 99 - 26 16 103 95 110 101 - - 27 12 89 18 S236 AKRRRLSS LRASTSK 6 503 - - 99 76 - - 99 - - - 25 24 13 11 - - 70 31 39 16 S240 RLSSLRAS TSKSESS 7 1044 - - 79 64 - - 90 - 108 62 108 99 101 93 - - 101 42 83 14 T241 LSSLRAST SKSESSQ 6 116 - - 4 4 - - 9 - 21 11 5 5 25 23 - - - - - 9 S242 SSLRASTS KSESSQK 7 194 - - 20 10 - - 28 - 16 9 5 5 25 23 - - 18 7 24 4 S244 LRASTSKS ESSQK__ 6 67 - - 4 4 - - 27 - 6 3 - - 4 4 - - 3 2 10 - S246 ASTSKSES SQK____ 1 14 - - - - - - - - - - - - - - - - 9 5 - - S247 STSKSESS QK_____ 2 23 - - - - - - 18 - - - - - - - - - 4 1 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S82 LLLSKGHS CYRPRRT 8.7e-11 - - - - - 8.8e-11 - - - - S235 IAKRRRLS SLRASTS -0.38 - - - - 9.0e-5 -2.1e-17 0.42 - 0.85 0.18 S236 AKRRRLSS LRASTSK 1.6e-3 - 4.1e-18 - - - -0.7 - - -3.8e-4 0.12 S240 RLSSLRAS TSKSESS 1e-22 - 1.3e-15 - - 6.4e-16 1.4e-6 5.2e-8 - -6.6e-5 0.095 T241 LSSLRAST SKSESSQ -9.8e-3 - - - - -0.19 - -0.019 - - - S242 SSLRASTS KSESSQK -0.74 - 0.049 - - - - -0.015 - - - S244 LRASTSKS ESSQK__ - - - - - - - - - - - S246 ASTSKSES SQK____ - - - - - - - - - - - S247 STSKSESS QK_____ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S82
S235
S236
S240
T241
S242
S244
S246
S247
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation CCRCC S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation COAD S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation GBM S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation HNSCC S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation LSCC S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation LUAD S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation OV S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation PDAC S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation UCEC S82 S235 S236 S240 T241 S242 S244 S246 S247 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S82
S235
S236
S240
T241
S242
S244
S246
S247
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S82
S235
S236
S240
T241
S242
S244
S246
S247
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.