SHROOM2: shroom family member 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5f4y chain A
5f4y chain B
5f5p chain A
5f5p chain B
5f5p chain G
5f5p chain H
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S116 ELGWRPHS WHATKFS 8 343 24 - 21 20 - - 18 - 39 24 55 50 25 23 - - 25 11 8 - S125 HATKFSDS HPELAAS 6 188 7 - 5 4 - - - - - - 65 59 9 8 20 5 - - 6 - S153 RHHASSSS HDLSSSW 1 8 8 - - - - - - - - - - - - - - - - - - - S157 SSSSHDLS SSWEQTN 1 8 8 - - - - - - - - - - - - - - - - - - - S159 SSHDLSSS WEQTNLQ 1 53 - - - - - - 53 - - - - - - - - - - - - - S174 RTLDHFSS LGSVDSL 4 52 8 - - - - - 9 - 6 3 - - - - 22 4 - - - - S177 DHFSSLGS VDSLDHP 3 79 8 - - - - - - - 19 9 - - - - 35 8 - - - - S193 SRLSVAKS NSSIDHL 7 266 18 - - - 5 4 28 - 57 34 49 44 - - 15 3 - - 7 2 S196 SVAKSNSS IDHLGSH 5 105 17 - - - - - - - 28 18 5 4 4 4 20 5 - - - - S202 SSIDHLGS HSKRDSA 1 9 - - - - - - - - - - 5 4 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S116 ELGWRPHS WHATKFS -6.4e-10 - -2.3e-4 - - -0.5 -2.5e-11 -1.4e-8 - 3.7e-3 - S125 HATKFSDS HPELAAS -7.6e-11 - - - - - -7.6e-11 - - - - S153 RHHASSSS HDLSSSW - - - - - - - - - - - S157 SSSSHDLS SSWEQTN - - - - - - - - - - - S159 SSHDLSSS WEQTNLQ - - - - - - - - - - - S174 RTLDHFSS LGSVDSL - - - - - - - - - - - S177 DHFSSLGS VDSLDHP - - - - - - - - - - - S193 SRLSVAKS NSSIDHL -0.91 - - - - 0.22 -0.16 - - - - S196 SVAKSNSS IDHLGSH -2.4e-7 - - - - -2.4e-7 - - - - - S202 SSIDHLGS HSKRDSA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S116
S125
S153
S157
S159
S174
S177
S193
S196
S202
S204
S208
S212
S214
S218
T219
S230
S231
S261
S312
S313
S323
S325
S377
S411
S413
S414
S415
S422
S451
S456
S464
S589
S623
S646
T647
T651
T755
S764
S779
S847
S851
S897
S921
S922
Y928
S933
T962
S974
S977
S1022
S1036
S1039
S1048
T1096
S1098
S1110
S1112
S1114
T1165
T1168
S1169
S1171
S1173
S1219
S1228
T1296
S1297
S1425
S1427
S1524
S1530
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation CCRCC S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation COAD S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation GBM S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation HNSCC S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation LSCC S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation LUAD S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation OV S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation PDAC S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation UCEC S116 S125 S153 S157 S159 S174 S177 S193 S196 S202 S204 S208 S212 S214 S218 T219 S230 S231 S261 S312 S313 S323 S325 S377 S411 S413 S414 S415 S422 S451 S456 S464 S589 S623 S646 T647 T651 T755 S764 S779 S847 S851 S897 S921 S922 Y928 S933 T962 S974 S977 S1022 S1036 S1039 S1048 T1096 S1098 S1110 S1112 S1114 T1165 T1168 S1169 S1171 S1173 S1219 S1228 T1296 S1297 S1425 S1427 S1524 S1530 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S116
S125
S153
S157
S159
S174
S177
S193
S196
S202
S204
S208
S212
S214
S218
T219
S230
S231
S261
S312
S313
S323
S325
S377
S411
S413
S414
S415
S422
S451
S456
S464
S589
S623
S646
T647
T651
T755
S764
S779
S847
S851
S897
S921
S922
Y928
S933
T962
S974
S977
S1022
S1036
S1039
S1048
T1096
S1098
S1110
S1112
S1114
T1165
T1168
S1169
S1171
S1173
S1219
S1228
T1296
S1297
S1425
S1427
S1524
S1530
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S116
S125
S153
S157
S159
S174
S177
S193
S196
S202
S204
S208
S212
S214
S218
T219
S230
S231
S261
S312
S313
S323
S325
S377
S411
S413
S414
S415
S422
S451
S456
S464
S589
S623
S646
T647
T651
T755
S764
S779
S847
S851
S897
S921
S922
Y928
S933
T962
S974
S977
S1022
S1036
S1039
S1048
T1096
S1098
S1110
S1112
S1114
T1165
T1168
S1169
S1171
S1173
S1219
S1228
T1296
S1297
S1425
S1427
S1524
S1530
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.