ARHGAP5: Rho GTPase activating protein 5
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ee4 chain A
2ee5 chain A
5u4v chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T289 TVRDYHAT WKTVSNK 2 17 - - 4 4 - - 9 - - - - - - - - - - - - - S540 KLAPDRES LLLKHIG 5 134 22 - 23 23 - - 53 - - - - - - - 7 2 - - 4 - S590 RLRLYHDS TNIDKVN 10 722 24 - 13 10 82 79 99 - 69 42 15 13 9 9 30 6 101 42 73 6 S683 GKIRTEAS QIRKDKY 1 9 - - - - - - - - - - - - - - 7 2 - - - - S706 ILANQRDS ISKNLPI 1 8 - - - - - - - - - - - - 4 4 - - - - - - S765 KHNLDVVS PIPANKD 10 1263 80 - 91 68 59 49 91 - 102 59 94 85 97 89 35 7 101 43 95 18 S961 TRESTHQS EDVFLPS 1 18 - - - - - - - - - - - - - - 15 3 - - - - S968 SEDVFLPS PRDCFPY 8 318 17 - - - 20 24 72 - 29 17 - - 23 19 70 16 4 1 6 - S981 PYNNYPDS DDDTEAP 7 243 8 - 17 16 43 47 16 - - - - - 9 8 - - 29 13 25 12 T985 YPDSDDDT EAPPPYS 5 89 30 - 12 11 - - 8 - - - - - - - - - 14 6 6 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T289 TVRDYHAT WKTVSNK - - - - - - - - - - - S540 KLAPDRES LLLKHIG -5.2e-4 - -5.2e-4 - - - - - - - - S590 RLRLYHDS TNIDKVN -2.5e-3 - - -0.019 - -2.3e-5 - - - 0.18 - S683 GKIRTEAS QIRKDKY - - - - - - - - - - - S706 ILANQRDS ISKNLPI - - - - - - - - - - - S765 KHNLDVVS PIPANKD -1.4e-7 - -3.3e-7 0.36 - -0.27 -1.4e-6 -0.082 - -4.2e-7 2.8e-3 S961 TRESTHQS EDVFLPS - - - - - - - - - - - S968 SEDVFLPS PRDCFPY -0.24 - - -0.18 - 0.084 - -0.78 -0.014 - - S981 PYNNYPDS DDDTEAP 0.062 - - -0.99 - - - - - 0.45 0.013 T985 YPDSDDDT EAPPPYS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T289
S540
S590
S683
S706
S765
S961
S968
S981
T985
Y991
S992
Y1091
S1115
S1124
T1129
S1138
S1142
S1173
S1176
S1184
S1195
S1202
T1217
S1218
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation CCRCC T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation COAD T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation GBM T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation HNSCC T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation LSCC T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation LUAD T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation OV T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation PDAC T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation UCEC T289 S540 S590 S683 S706 S765 S961 S968 S981 T985 Y991 S992 Y1091 S1115 S1124 T1129 S1138 S1142 S1173 S1176 S1184 S1195 S1202 T1217 S1218 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T289
S540
S590
S683
S706
S765
S961
S968
S981
T985
Y991
S992
Y1091
S1115
S1124
T1129
S1138
S1142
S1173
S1176
S1184
S1195
S1202
T1217
S1218
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T289
S540
S590
S683
S706
S765
S961
S968
S981
T985
Y991
S992
Y1091
S1115
S1124
T1129
S1138
S1142
S1173
S1176
S1184
S1195
S1202
T1217
S1218
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.