Protein: ENSP00000372035
Gene: LATS2

LinkedOmicsKB © 2022-2023 Zhang Lab

LATS2:
large tumor suppressor kinase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S43GLPAGPNSDTSLDAK712330-2220--9---5598--3210-
S272LGYGVQRSPSFQSKT217--54--------44------
S274YGVQRSPSFQSKTPP8401--44141335-7543--10844836167615
T279SPSFQSKTPPETGGY115------------------132
S342SQVFASDSPPQSLLT731123-1410--18---30285043204--647
S380ATLARRDSLQKPGLE435366---6668------6258276----
S408PVPSRTNSFNSHQPR10108973-4628515690-593298897569831989377718
S411SRTNSFNSHQPRPGP2149---------------32--
S528HLLLRSKSEQYDLDS71779---71136---44--276104536
Y531LRSKSEQYDLDSLCA2178-------------81----
Showing 1 to 10 of 18 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S43GLPAGPNSDTSLDAK-6.4e-3--6.4e-3--------
S272LGYGVQRSPSFQSKT-----------
S274YGVQRSPSFQSKTPP0.034----9.9e-7----0.4-0.7
T279SPSFQSKTPPETGGY-----------
S342SQVFASDSPPQSLLT-4.4e-4------7.3e-3-0.022---
S380ATLARRDSLQKPGLE-1.5e-14---1.0e-5----1.1e-10---
S408PVPSRTNSFNSHQPR-2.6e-10--2.7e-4-8.4e-3-0.06-1.7e-19-2.3e-120.04-0.960.57
S411SRTNSFNSHQPRPGP-----------
S528HLLLRSKSEQYDLDS-----------
Y531LRSKSEQYDLDSLCA-----------
Showing 1 to 10 of 18 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationCCRCCS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationCOADS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationGBMS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationHNSCCS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationLSCCS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationLUADS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationOVS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationPDACS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylationUCECS43S272S274T279S342S380S408S411S528Y531S535T575S576S835S1015S1018T1026S1069proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.