ALK: ALK receptor tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2kup chain B
2kuq chain A
2xb7 chain A
2xba chain A
2xp2 chain A
2yfx chain A
2yhv chain A
2yjr chain A
2yjs chain A
2ys5 chain B
2yt2 chain A
3aox chain A
3l9p chain A
3lcs chain A
3lct chain A
4anl chain A
4anq chain A
4ans chain A
4ccb chain A
4ccu chain A
4cd0 chain A
4cli chain A
4clj chain A
4cmo chain A
4cmt chain A
4cmu chain A
4cnh chain A
4cnh chain B
4ctb chain A
4ctc chain A
4dce chain A
4dce chain B
4fnw chain A
4fnx chain A
4fny chain A
4fnz chain A
4fob chain A
4foc chain A
4fod chain A
4joa chain A
4mkc chain A
4tt7 chain A
4z55 chain A
5a9u chain A
5aa8 chain A
5aa9 chain A
5aaa chain A
5aab chain A
5aac chain A
5fto chain A
5ftq chain A
5imx chain A
5iug chain A
5iuh chain A
5iui chain A
5kz0 chain A
5vz5 chain C
6at9 chain C
6cdt chain A
6e0r chain A
6ebw chain A
6edl chain A
6mx8 chain A
7btt chain A
7jy4 chain A
7jyr chain A
7jys chain A
7jyt chain A
7lrz chain A
7ls0 chain A
7ls0 chain B
7ls0 chain C
7ls0 chain D
7mzw chain A
7mzy chain A
7mzy chain B
7n00 chain A
7n00 chain C
7nwz chain A
7nwz chain B
7nwz chain E
7nwz chain F
7nx3 chain A
7nx3 chain F
7nx4 chain A
7r7k chain A
7r7r chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S1075 AMQMELQS PEYKLSK 1 9 - - - - - - - - - - - - 5 4 - - - - - - Y1096 MTDYNPNY CFAGKTS 1 8 - - - - - - - - - - - - 4 4 - - - - - - Y1507 TSLWNPTY GSWFTEK 1 57 - - - - - - - - - - - - 31 26 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S1075 AMQMELQS PEYKLSK - - - - - - - - - - - Y1096 MTDYNPNY CFAGKTS - - - - - - - - - - - Y1507 TSLWNPTY GSWFTEK 0.42 - - - - - - 0.42 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S1075
Y1096
Y1507
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S1075 Y1096 Y1507 protein RNA SCNV methylation CCRCC S1075 Y1096 Y1507 protein RNA SCNV methylation COAD S1075 Y1096 Y1507 protein RNA SCNV methylation GBM S1075 Y1096 Y1507 protein RNA SCNV methylation HNSCC S1075 Y1096 Y1507 protein RNA SCNV methylation LSCC S1075 Y1096 Y1507 protein RNA SCNV methylation LUAD S1075 Y1096 Y1507 protein RNA SCNV methylation OV S1075 Y1096 Y1507 protein RNA SCNV methylation PDAC S1075 Y1096 Y1507 protein RNA SCNV methylation UCEC S1075 Y1096 Y1507 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S1075
Y1096
Y1507
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S1075
Y1096
Y1507
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.