Protein: ENSP00000373706
Gene: DIAPH1

LinkedOmicsKB © 2022-2023 Zhang Lab

DIAPH1:
diaphanous related formin 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S22RDKKKGRSPDELPSA10118647-3025727199-9755108999185481297419118
S208EKEETAGSYDSRNKH19----------54--------
Y374EQGEEDSYDLKGRLD120----------1010--------
S866NLSIFLGSFRMPYQE18--44----------------
S1051VEKASRVSAENLQKN6229--4535--63-632421----93182
S1231KAGCAVTSLLASELT393--1615------10102319------
S1251AAVPAKVSKNSETFP17--43----------------
S1254PAKVSKNSETFPTIL7456--3130--62-3216556660--35148218
T1256KVSKNSETFPTILEE5105--1212------20181411--51102
S1272KELVGRAS_______4136--5039----178--89--32--
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S22RDKKKGRSPDELPSA4.7e-21-1.8e-41e-13--0.33.6e-53.6e-138.6e-4-3.5e-41e-7
S208EKEETAGSYDSRNKH-----------
Y374EQGEEDSYDLKGRLD-----------
S866NLSIFLGSFRMPYQE-----------
S1051VEKASRVSAENLQKN-2.2e-18--3.6e-16----2.5e-5----
S1231KAGCAVTSLLASELT0.26------0.26---
S1251AAVPAKVSKNSETFP-----------
S1254PAKVSKNSETFPTIL6.3e-8-1.8e-11---0.15-8.5e-6-0.260.21
T1256KVSKNSETFPTILEE-0.055------0.055----
S1272KELVGRAS_______2.9e-4-2.9e-4--------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK1S224.4e-221.1e-30.0760.0580.215.5e-71.8e-45.4e-50.0935.5e-33e-7
PERT-PSP_NOCODAZOLES222.5e-200.0230.0430.376.9e-38.0e-51.8e-42.2e-50.110.024.7e-8
KINASE-PSP_CDK2S222.2e-180.0254.9e-30.210.0252.1e-30.158.6e-60.0888.6e-56.9e-6
HALLMARK_G2M_CHECKPOINTS222.1e-150.0110.0620.150.0183.1e-30.0456.9e-40.192.9e-43.8e-4
HALLMARK_E2F_TARGETSS223.7e-156.7e-30.0520.0270.0150.0520.141.2e-30.181.9e-41.4e-4
HALLMARK_MYC_TARGETS_V2S221.3e-140.0758.8e-40.460.384.7e-50.22.1e-30.39.9e-51.6e-5
HALLMARK_MTORC1_SIGNALINGS226.7e-130.0720.0169.5e-30.221.7e-30.129.1e-30.0350.0893.8e-4
HALLMARK_MYC_TARGETS_V1S227.4e-130.374.9e-30.180.141.6e-40.0050.0190.281.3e-30.004
PROGENy: PI3KS222.7e-120.960.420.150.254.2e-80.0171.7e-30.0478.7e-32.3e-3
HALLMARK_GLYCOLYSISS225.1e-120.117.9e-40.30.416.6e-40.632.5e-50.320.0127.3e-4
Showing 1 to 10 of 2580 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationCCRCCS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationCOADS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationGBMS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationHNSCCS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationLSCCS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationLUADS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationOVS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationPDACS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylationUCECS22S208Y374S866S1051S1231S1251S1254T1256S1272proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.