SPTB: spectrin beta, erythrocytic
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1s35 chain A
3edu chain A
3f57 chain A
3f57 chain B
3kbt chain A
3kbt chain B
3kbu chain A
3kbu chain B
3lbx chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S35 DELDNDNS SARLFER 7 306 - - 74 52 5 4 - - 37 21 10 9 37 31 7 1 14 4 - - S36 ELDNDNSS ARLFERS 10 651 22 - 46 44 44 45 89 - 10 7 34 30 39 36 47 12 50 20 60 16 T382 ANNQKVYT PHDGKLV 10 723 33 - 40 31 5 4 72 - 65 33 88 81 92 85 47 12 12 5 7 11 S816 FPEEFRDS PDVTHRL 1 9 - - - - - - - - - - 5 4 - - - - - - - - S998 IAIQRKLS GLERDVA 1 32 32 - - - - - - - - - - - - - - - - - - - S1018 VDALERES QQLMDSH 1 9 9 - - - - - - - - - - - - - - - - - - - S1024 ESQQLMDS HPEQKED 1 9 9 - - - - - - - - - - - - - - - - - - - S1092 ASEDMPES LPEAEQL 1 8 - - 8 - - - - - - - - - - - - - - - - - S1226 NNRDKVLS PVDSGNK 10 968 35 - 78 56 3 6 99 - 101 59 108 99 101 93 22 4 61 26 8 9 S1396 ADLNKWIS AMEDQLR 3 225 - - - - - - 8 - - - 44 40 68 65 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S35 DELDNDNS SARLFER -1.3e-5 - 1.7e-7 - - -4.8e-5 - -2.7e-18 - - - S36 ELDNDNSS ARLFERS -1.5e-22 - 1.3e-3 -2.9e-7 - - -5.1e-7 -1e-11 -1.9e-8 -3.8e-6 -0.062 T382 ANNQKVYT PHDGKLV -4.3e-30 - 3.7e-4 - - -1.3e-4 -1.7e-25 -1.2e-26 -4.1e-5 - - S816 FPEEFRDS PDVTHRL - - - - - - - - - - - S998 IAIQRKLS GLERDVA - - - - - - - - - - - S1018 VDALERES QQLMDSH - - - - - - - - - - - S1024 ESQQLMDS HPEQKED - - - - - - - - - - - S1092 ASEDMPES LPEAEQL - - - - - - - - - - - S1226 NNRDKVLS PVDSGNK -3.3e-19 - 4.4e-8 - - -1.8e-5 -9.8e-32 -1.7e-7 - -2.0e-5 - S1396 ADLNKWIS AMEDQLR -1.3e-32 - - - - - -1.2e-21 -3.8e-13 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S35
S36
T382
S816
S998
S1018
S1024
S1092
S1226
S1396
T1531
S1715
S1833
S1937
S1960
S2019
Y2031
S2034
T2040
S2043
S2060
T2073
T2098
S2105
T2110
T2113
S2114
S2117
S2123
S2124
S2125
S2128
S2134
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation CCRCC S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation COAD S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation GBM S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation HNSCC S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation LSCC S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation LUAD S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation OV S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation PDAC S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation UCEC S35 S36 T382 S816 S998 S1018 S1024 S1092 S1226 S1396 T1531 S1715 S1833 S1937 S1960 S2019 Y2031 S2034 T2040 S2043 S2060 T2073 T2098 S2105 T2110 T2113 S2114 S2117 S2123 S2124 S2125 S2128 S2134 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S35
S36
T382
S816
S998
S1018
S1024
S1092
S1226
S1396
T1531
S1715
S1833
S1937
S1960
S2019
Y2031
S2034
T2040
S2043
S2060
T2073
T2098
S2105
T2110
T2113
S2114
S2117
S2123
S2124
S2125
S2128
S2134
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S35
S36
T382
S816
S998
S1018
S1024
S1092
S1226
S1396
T1531
S1715
S1833
S1937
S1960
S2019
Y2031
S2034
T2040
S2043
S2060
T2073
T2098
S2105
T2110
T2113
S2114
S2117
S2123
S2124
S2125
S2128
S2134
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.