Protein: ENSP00000375709
Gene: AKT1S1

LinkedOmicsKB © 2022-2023 Zhang Lab

AKT1S1:
AKT1 substrate 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S88PPAPQPPSPTPSPPR101364113-9572869399-10862103931101017294407016
T90APQPPSPTPSPPRPT1061123-3625929627-2313103942519115856-
S92QPPSPTPSPPRPTLA1050727-3230453672-189252231291154219504
S183PTQQYAKSLPVSVPV10113582-46449710099-513048448277791893379018
T198WGFKEKRTEARSSDE127------27-------------
S202EKRTEARSSDEENGP10806104-7658889199-623715131716531058918
S203KRTEARSSDEENGPP10113181-6856918899-7846595445454712105449518
S211DEENGPPSSPDLDRI930797-1312111672-1510201944--4253
S212EENGPPSSPDLDRIA1064736-54737163-1682522403747117733709
T246LPRPRLNTSDFQKLK101459104-9280787599-1086210395106978319102439518
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S88PPAPQPPSPTPSPPR2.3e-9-1.1e-30.072--6.3e-31.2e-80.02-9.1e-40.032
T90APQPPSPTPSPPRPT-3.1e-3--0.150.74--1.3e-3-0.26-0.24---
S92QPPSPTPSPPRPTLA2.8e-3--9.7e-80.023--6.4e-47.8e-3-2.5e-4-
S183PTQQYAKSLPVSVPV-4.6e-36-1.0e-4-3.6e-29--3.4e-12-4.3e-19-1.2e-20-0.0470.13-0.014
T198WGFKEKRTEARSSDE-----------
S202EKRTEARSSDEENGP-0.3--0.280.021--0.47-----0.01
S203KRTEARSSDEENGPP4e-13--1.2e-61.1e-16-4e-112.6e-142.5e-6-0.37-0.53-0.74
S211DEENGPPSSPDLDRI0.9-----0.9----
S212EENGPPSSPDLDRIA-0.51---0.7--0.0821.5e-4-0.11-5.6e-7-
T246LPRPRLNTSDFQKLK-5.8e-25-1.7e-18-3.2e-20--1.1e-13-1e-17-1.7e-20-1.3e-50.990.15
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationCCRCCS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationCOADS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationGBMS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationHNSCCS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationLSCCS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationLUADS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationOVS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationPDACS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylationUCECS88T90S92S183T198S202S203S211S212T246S247proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.