XRCC5: X-ray repair cross complementing 5
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1jeq chain B
1jey chain B
1q2z chain A
1rw2 chain A
3rz9 chain B
5y3r chain B
6erf chain B
6erf chain D
6erf chain F
6erf chain H
6erg chain B
6erg chain E
6erh chain B
6erh chain D
6zh6 chain B
6zha chain C
6zhe chain C
6zhe chain H
7axz chain B
7k0y chain C
7k17 chain C
7k17 chain D
7k1j chain C
7k1k chain C
7k1n chain C
7lsy chain B
7lsy chain K
7lt3 chain B
7lt3 chain K
7nfc chain C
7nfc chain H
7nfe chain C
7sgl chain C
7su3 chain C
7sud chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S145 LSSRFSKS QLDIIIH 8 821 79 - 64 52 - - 54 - 79 44 108 99 106 98 - - 12 5 19 2 S175 SLGKEDGS GDRGDGP 5 154 - - - - - - 18 - 25 12 34 33 4 4 19 5 - - - - S191 RLGGHGPS FPLKGIT 1 8 - - - - - - - - - - - - - - - - - - 8 - S244 FKKIERHS IHWPCRL 5 43 8 - 5 4 5 4 - - 7 3 - - - - - - - - 7 - S255 PCRLTIGS NLSIRIA 2 42 - - - - - - - - - - 10 8 - - - - - - 13 11 S258 LTIGSNLS IRIAAYK 4 112 24 - - - - - - - 30 14 20 17 - - - - 5 2 - - S318 IQGFRYGS DIVPFSK 8 233 17 - 4 4 - - 9 - 28 17 40 38 18 15 - - 3 2 27 11 S437 LRQYMFSS LKNSKKY 6 199 7 - - - - - 9 - 34 22 44 40 - - - - 17 5 19 2 S460 AVDALIDS MSLAKKD 1 10 - - - - - - 10 - - - - - - - - - - - - - T472 KKDEKTDT LEDLFPT 2 35 - - - - - - - - - - 9 9 - - - - - - 12 5
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S145 LSSRFSKS QLDIIIH 3.5e-10 - -8.7e-3 - - 0.28 3.6e-24 8.1e-5 - - - S175 SLGKEDGS GDRGDGP 1.7e-8 - - - - 4.6e-5 9.4e-5 - - - - S191 RLGGHGPS FPLKGIT - - - - - - - - - - - S244 FKKIERHS IHWPCRL - - - - - - - - - - - S255 PCRLTIGS NLSIRIA - - - - - - - - - - - S258 LTIGSNLS IRIAAYK 0.47 - - - - -0.77 0.19 - - - - S318 IQGFRYGS DIVPFSK 0.005 - - - - -0.031 4.1e-10 - - - 0.45 S437 LRQYMFSS LKNSKKY 9e-12 - - - - 8.0e-6 2.2e-7 - - - - S460 AVDALIDS MSLAKKD - - - - - - - - - - - T472 KKDEKTDT LEDLFPT - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S145
S175
S191
S244
S255
S258
S318
S437
S460
T472
S526
S531
T549
S577
S579
S580
S608
S692
S695
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation CCRCC S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation COAD S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation GBM S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation HNSCC S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation LSCC S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation LUAD S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation OV S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation PDAC S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation UCEC S145 S175 S191 S244 S255 S258 S318 S437 S460 T472 S526 S531 T549 S577 S579 S580 S608 S692 S695 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S145
S175
S191
S244
S255
S258
S318
S437
S460
T472
S526
S531
T549
S577
S579
S580
S608
S692
S695
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S145
S175
S191
S244
S255
S258
S318
S437
S460
T472
S526
S531
T549
S577
S579
S580
S608
S692
S695
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.